HCV Infection and Cryoglobulinemia

Editors: Dammacco, Franco (Ed.)

  • A comprehensive review of cryoglobulinemia for scientists and specialists of many disciplines
  • Discusses cryoglobulinemic patients and potential susceptibility to non-Hodgkin’s lymphoma
  • Offers striking illustrations and color plates
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  • ISBN 978-88-470-1704-7
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About this book

The first observation of cold-induced precipitation of serum proteins dates back to 1933, when Wintrobe and Buell first described an unusual case of multiple myeloma in a woman whose serum reversibly precipitated at cold temperatures. In 1947 Lerner and Watson showed cold-precipitable proteins to be gammaglobulins and called them ‘cryoglobulins’ and the corresponding clinical condition ‘cryoglobulinemia’. Meltzer and Franklin in 1966 provided an accurate description of the typical clinical symptoms associated with cryoglobulinemia, showed that they consisted of two different globulin components and, because of the ignorance on its etiology, called this clinical condition ‘essential mixed cryoglobulinemia’. For almost 20 years progress has been rather slow in this field, but when at the end of the ‘80s it finally became possible to detect the occurrence in the serum of antibodies to the hepatitis C virus (HCV), many groups in Europe and the United States almost simultaneously reported that a high proportion of ‘essential’ cryoglobulinemias are in fact associated with HCV infection. This hallmark has resulted in a new impetus and great enthusiasm in carrying out new researches made possible by the awareness that cryoglobulinemia is to be considered an undisputable extrahepatic manifestation of HCV infection. In addition, the evidence that HCV has tropism for hepatocytes and lymphocytes has stimulated new approaches to the autoimmune phenomena and the potential transformation in non-Hodgkin’s lymphomas which not infrequently can be discovered in these patients. The same applies to the obvious therapeutic implications, once the association between HCV infection and mixed cryoglobulinemia has been firmly established. It was thus felt that times were ripe to produce a state-of-the-art survey of the multi-faceted picture of cryoglobulinemia. This book is indeed unique in the detail of its presentation, its completeness and its fundamental approach to the subject. The most qualified authors have been invited to contribute critical articles reviewing significant developments related to each of the eight sections in which the whole treatment has been divided: from basic mechanisms governing interactions between HCV and the immune system to the immunochemical characterization of cryoglobulins and the frequently concomitant serological abnormalities; from genetic features and the role of certain cytokines and chemokines to the cellular compartments of HCV infection and replication; from the clinical manifestations of cryoglobulinemic patients and their potential susceptibility to develop non-Hodgkin’s lymphoma to conventional treatment of the syndrome and the newer, promising therapeutic advances. The reader will appreciate the immediacy of style, the striking illustrations, and the color plates. In addition, the comprehensive review of a systemic disease such as cryoglobulinemia will interest basic scientists and specialists involved in several disciplines, including internal medicine, hepatology, hematology, oncology, infectious diseases, rheumatology, nephrology and dermatology. General practitioners, graduate and post-graduate students will also find in this book an irreplaceable source of update in this fascinating field.

Table of contents (45 chapters)

  • Introductory Remarks

    Dammacco, Franco (et al.)

    Pages 1-8

  • Natural History, Pathogenesis, and Prevention of HCV Infection

    Charles, Edgar D. (et al.)

    Pages 11-19

  • Immune Control of HCV Infection

    Dustin, Lynn B.

    Pages 21-36

  • B Cell Activation: General to HCV-Specific Considerations

    Racanelli, Vito (et al.)

    Pages 37-41

  • Organ-Specific Autoimmunity in HCV-Positive Patients

    Betterle, Corrado (et al.)

    Pages 43-51

Buy this book

eBook $199.00
price for USA (gross)
  • ISBN 978-88-470-1705-4
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $259.00
price for USA
  • ISBN 978-88-470-1704-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $259.00
price for USA
  • ISBN 978-88-470-5581-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Rent the ebook  
  • Rental duration: 1 or 6 month
  • low-cost access
  • online reader with highlighting and note-making option
  • can be used across all devices
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Bibliographic Information

Bibliographic Information
Book Title
HCV Infection and Cryoglobulinemia
Editors
  • Franco Dammacco
Copyright
2012
Publisher
Springer-Verlag Mailand
Copyright Holder
Springer-Verlag Italia
eBook ISBN
978-88-470-1705-4
DOI
10.1007/978-88-470-1705-4
Hardcover ISBN
978-88-470-1704-7
Softcover ISBN
978-88-470-5581-0
Edition Number
1
Number of Pages
XVIII, 362
Topics