Topics in Neuroscience

Early Indicators Early Treatments Neuroprotection in Multiple Sclerosis

Authors: Hommes, O.R., Comi, G.

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About this book

There is now evidence that irreversible brain damage accumulates very early in the course of multiple sclerosis. This book reviews the main neurobiological, magnetic resonance imaging, and clinical aspects of the early phases of the dis­ ease. Mechanisms ofirreversible axonal damage and the role played by the inter­ action of glia and the axon are highlighted. In contrast to what was believed for a long time, the sufficient availability of oligodendrocyte precursor cells to promote remyelination in acute lesions has now been demonstrated. For reasons not understood, this remyelination process fails or does not start, particularly in the chronic stages ofthe disease. These findings emphasize the importance of the "milieu" changes induced by an inflammatory process in limiting remyelination. However, first indications are that part of this inflammatory process may have a neuroprotective effect. Pathological studies in multiple sclerosis have now clearly demonstrated that destructive processes may be followed by recovery phases in such a way that myelin may be morphologically and functionally reconstituted. These findings provide the rationale for early treatment and emphasize the importance of clinical trials in early multiple sclerosis. Early treatment is one of the most important aspects in multiple sclerosis today.

Table of contents (20 chapters)

  • Evidence for an Early Treatment of Multiple Sclerosis

    Comi, G. (et al.)

    Pages 1-13

  • Inflammation, Demyelination, and Axonal Degeneration: Three Aspects of the Pathogenesis of Multiple Sclerosis Revealed by Campath-1H Treatment

    Coles, A. J. (et al.)

    Pages 15-25

  • Genetic Regulation of Nerve Cell Death/Glial Activation and Protective Effects of Myelin Basic Protein Autoimmune Neurotrophin Production in Mechanically Induced Neurodegeneration

    Piehl, F. (et al.)

    Pages 27-39

  • Neuroprotective Treatment in Primary Progressive Multiple Sclerosis: a Phase I/II Study with Riluzole

    Kalkers, N. (et al.)

    Pages 41-47

  • Neuropathology and Disease Progression in Multiple Sclerosis

    Bjartmar, C. (et al.)

    Pages 49-61

Buy this book

eBook $119.00
price for USA (gross)
  • ISBN 978-88-470-2117-4
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $209.00
price for USA
  • ISBN 978-88-470-0195-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $159.00
price for USA
  • ISBN 978-88-470-2171-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Early Indicators Early Treatments Neuroprotection in Multiple Sclerosis
Authors
Series Title
Topics in Neuroscience
Copyright
2004
Publisher
Springer-Verlag Mailand
Copyright Holder
Springer-Verlag Italia
eBook ISBN
978-88-470-2117-4
DOI
10.1007/978-88-470-2117-4
Hardcover ISBN
978-88-470-0195-4
Softcover ISBN
978-88-470-2171-6
Edition Number
1
Number of Pages
XV, 199
Topics