How the Immune System Recognizes Self and Nonself

Immunoreceptors and Their Signaling

Editors: Kitamura, Daisuke (Ed.)

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About this book

How do you discriminate yourself from other people? This question must sound odd to you since you easily recognize others at a glance and, without any effort, would not mistake them for yourself. However, it is not always easy for some people to discriminate themselves from others. For example, patients with schi- phrenia often talk with “others” living inside themselves. Thus it is likely that n- mally your brain actively recognizes and remembers the information belonging to yourself and discriminates it from the information provided by others, although you are not conscious of it. This brain function must have been particularly important for most animals to protect their lives from enemies and for species to survive through evolution. Similarly, higher organisms have also acquired their immune system through evolution that discriminates nonself pathogens and self-body to protect their lives from pathogens such as bacteria or viruses. The brain system may distinguish integrated images of self and nonself created from many inputs, such as vision, sound, smell, and others. The immune system recognizes and distinguishes a variety of structural features of self and nonself components. The latter actually include almost everything but self: for example, bacteria, viruses, toxins, pollens, chemicals, transplanted organs, and even tumor cells derived from self-tissue. To this end the immune system recruits different kinds of immune cells, such as B and T lymphocytes, natural killer (NK) cells, dendritic cells, and macrophages.

Table of contents (8 chapters)

  • Recognition of Pathogens: Toll-Like Receptors

    Uematsu, Satoshi (et al.)

    Pages 1-36

  • Strategies of Natural Killer (NK) Cell Recognition and Their Roles in Tumor Immunosurveillance

    Stewart, C. Andrew (et al.)

    Pages 37-81

  • Recent Progress on Paired Immunoglobulin-Like Receptors

    Kubagawa, Hiromi (et al.)

    Pages 83-98

  • Self-nonself Recognition through B-Cell Antigen Receptor

    Kitamura, Daisuke

    Pages 99-132

  • How Do T Cells Discriminate Self from Nonself?

    Mazza, Catherine (et al.)

    Pages 133-171

Buy this book

eBook $159.00
price for USA (gross)
  • ISBN 978-4-431-73884-8
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $209.00
price for USA
  • ISBN 978-4-431-73883-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $209.00
price for USA
  • ISBN 978-4-431-99831-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
How the Immune System Recognizes Self and Nonself
Book Subtitle
Immunoreceptors and Their Signaling
Editors
  • Daisuke Kitamura
Copyright
2008
Publisher
Springer Japan
Copyright Holder
Springer-Verlag Tokyo
eBook ISBN
978-4-431-73884-8
DOI
10.1007/978-4-431-73884-8
Hardcover ISBN
978-4-431-73883-1
Softcover ISBN
978-4-431-99831-0
Edition Number
1
Number of Pages
XVIII, 251
Number of Illustrations and Tables
6 illustrations in colour
Topics