Cell Therapy

1. Front Matter

   Pages I-XVI

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2. Immunotherapy for Malignant Diseases

   1. Front Matter

      Pages 1-1

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   2. Breaking Immunological Tolerance to Tumor Cells as a Novel Immunotherapy for Cancer

      • Shimon Sakaguchi, Takeshi Takahashi, Jun Shimizu

      Pages 3-13

   3. SART1 Gene Encoding Squamous Cell Carcinoma Antigen Recognized by Cytotoxic T Lymphocytes

      • Kyogo Itoh, Shigeki Shichijo, Yoshiko Inoue, Akihiro Hayashi, Uhi Toh, Hideaki Yamana

      Pages 15-28

   4. Adoptive Immunotherapy of Human Diseases with Antigen-Specific T-Cell Clones

      • Stanley R. Riddell, Edus H. Warren, Deborah Lewinsohn, Scott Brodie, Rici De Fries, Lawrence Corey et al.

      Pages 29-44

   5. Adoptive Transfer of Polyclonal, EBV-Specific Cytotoxic T-Cell Lines for the Prevention and Treatment of EBV-Associated Malignancies

      • Cliona M. Rooney, M. Helen Huls, Richard A. Rochester, Malcolm K. Brenner, Helen E. Heslop

      Pages 45-60

   6. Processing of Antigens by Dendritic Cells: Nature’s Adjuvant

      • Kayo Inaba

      Pages 61-68

   7. Immunotherapy of Melanoma Using Dendritic Cells

      • Frank O. Nestle

      Pages 69-76

   8. Immunotherapy of Melanoma Using T-Cell-Defined Antigens

      • Yutaka Kawakami

      Pages 77-92

3. Hematopoietic Stem Cells Biology and Clinical Application

   1. Front Matter

      Pages 93-93

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   2. Isolation and Characterization of CD34-Low/Negative Mouse Hematopoietic Stem Cells

      • Hiromitsu Nakauchi, Masatake Osawa, Kazuhiro Sudo, Hideo Ema

      Pages 95-103

   3. Ex Vivo Expansion of Human Hematopoietic Stem Cells

      • Tatsutoshi Nakahata, Ming-Jiang Xu, Takahiro Ueda, Sahoko Matsuoka, Mamoru Ito, Kohichiro Tsuji

      Pages 105-106

   4. Notch in Hematopoiesis: Cell Fate Decisions and Self-Renewal of Progenitors

      • Laurie A. Milner, Anna Bigas

      Pages 107-121

   5. Molecular Genetics of Acute Promyelocytic Leukemia: A Rationale for “Transcription Therapy” for Cancer

      • Pier Paolo Pandolfi

      Pages 123-132

   6. A Novel Acute Promyelocytic Leukemia Model: From Cell to Murine System

      • Masahiro Kizaki

      Pages 133-142

   7. Phase 1 Trial of Retroviral-Mediated Transfer of the Human MDR-1 in Patients Undergoing High-Dose Chemotherapy and Autologous Stem Cell Transplantation

      • Charles Hesdorffer, Janet Ayello, Maureen Ward, Andreas Kaubisch, Arthur Bank, Karen Antman

      Pages 143-157

   8. Basic Studies Toward Hematopoietic Stem Cell Gene Therapy

      • Yutaka Hanazono, Cynthia E. Dunbar, Robert E. Donahue, Ikunoshin Kato, Yasuji Ueda, Mamoru Hasegawa et al.

      Pages 159-169

   9. Ex Vivo Expansion of Hematopoietic Cells

      • Ian McNiece, Roy Jones, Pablo Cagnoni, Scott Bearman, Yago Nieto, Elizabeth J. Shpall

      Pages 171-183

   10. Harnessing Graft-Versus-Leukemia Without Myeloablative Therapy

       • Sergio A. Giralt

       Pages 185-193

   11. Ex Vivo Expansion of Human Cord Blood Stem Cells and Genetic Manipulation

       • Kiyoshi Ando, Hiroshi Kawada, Takashi Shimizu, Takashi Tsuji, Yoshihiko Nakamura, Minoru Kimura et al.

       Pages 195-204

Modern cell biology has brought improvements in therapy for advanced malignant diseases through immunomodulation, hematopoietic stem cell transplantation, and other advanced techniques. Collected here are selected papers from the Fifth International Symposium of Keio University for Life Sciences and Medicine on Cell Therapy.
All chapters include innovative basic research for clinical application: immunotherapy, cancer vaccination, molecular biology of hematopoietic stem cells, stem cell processing, and gene therapy.
The book is divided into three parts: Immunotherapy for malignant diseases; Hematopoietic stem cell biology and clinical application; and International collaboration in hematopoietic stem cell transplantation. Included in the third part is information on bone marrow registries from around the world.
The book thus presents up-to-date information on biological and clinical aspects of treatment, with insight into the future of cell therapy.

• Carcinom
• Vivo
• bone
• bone marrow tranplantation
• cell biology
• cells
• gene therapy
• hematopoietic stem cell
• immunotherapy

• Department of Internal Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan

  Yasuo Ikeda, Yutaka Hattori

• Department of Pathology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan

  Jun-ichi Hata

• Department of Microbiology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan

  Shigeo Koyasu

• Institute for Advanced Medical Research, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan

  Yutaka Kawakami

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