Photoaffinity Labeling for Structural Probing Within Protein

Editors: Hatanaka, Yasumaru, Hashimoto, Makoto (Eds.)

  • Provides a reliable strategy to probe molecular targets during the early stages of drug discovery and development
  • Describes the potential of updated photoaffinity labeling among chemical methods for the structural elucidation of proteins
  • Clarifies the chemical biology for the design and development of high-performance photoaffinity probes
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eBook $159.00
price for USA (gross)
  • ISBN 978-4-431-56569-7
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $209.00
price for USA
  • ISBN 978-4-431-56568-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This book covers the most up-to-date photoaffinity labeling method to tackle the key loop module involved in the binding process of a bioactive small molecule to its host protein. The book introduces rational points for preparing powerful photoaffinity probes, keys for the efficient analysis of labeled products, and recent successful applications for protein probing. Regarding drug design, the unique topics of the book are the special consideration of the crosslinking potential of recent probes and their application of important receptor proteins . This book presents emerging technologies of photoaffinity labeling to readers who are working in the fields of proteomics, molecular recognition, and drug discovery and development.

About the authors

​Yasumaru Hatanaka, PhD
Executive Vice President, University of ToyamaToyama, Japan

Makoto Hashimoto, PhD
Graduate School of Agriculture, Hokkaido University
Sapporo, Japan

Table of contents (12 chapters)

  • Multifunctional Photoprobes for Identification of Ligand Sites Within Biomolecules

    Hashimoto, Makoto

    Pages 1-11

  • Tag-Creation Approaches for Highly Efficient Profiling of Interacting Proteins and Domains

    Tomohiro, Takenori

    Pages 13-43

  • Recent Developments in Designing Compact Biological Photoprobes

    Wands, Amberlyn M. (et al.)

    Pages 45-78

  • Utilities of Anti-ligand Antibody and Mass Spectrum to Elucidate Photolabeled Sites

    Kawahara, Kohichi (et al.)

    Pages 79-92

  • Combination of Photoaffinity Label and Site-Directed Antibody for Target Proteins

    Kuniyasu, Akihiko (et al.)

    Pages 93-110

Buy this book

eBook $159.00
price for USA (gross)
  • ISBN 978-4-431-56569-7
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $209.00
price for USA
  • ISBN 978-4-431-56568-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Photoaffinity Labeling for Structural Probing Within Protein
Editors
  • Yasumaru Hatanaka
  • Makoto Hashimoto
Copyright
2017
Publisher
Springer Japan
Copyright Holder
Springer Japan KK
eBook ISBN
978-4-431-56569-7
DOI
10.1007/978-4-431-56569-7
Hardcover ISBN
978-4-431-56568-0
Edition Number
1
Number of Pages
VIII, 265
Number of Illustrations and Tables
100 b/w illustrations, 48 illustrations in colour
Topics