Editors:
Reviews advances in research and treatment of paroxysmal nocturnal hemoglobinuria (PNH)
Examines the role of eculizumab in management strategies
Overviews briefly the history and basic and clinical science of PNH
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Table of contents (21 chapters)
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Front Matter
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Basic Sciences in PNH
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Front Matter
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Clinical Sciences in PNH
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Front Matter
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About this book
This volume reviews the fundamental understanding of this potentially life-threatening disease and the advances in treatment that have been achieved with the use of the monoclonal antibody eculizumab. Although the PIGA gene has been known for many years, the mechanism of clonal dominance in paroxysmal nocturnal hemoglobinuria is still largely unknown. This book, Paroxysmal Nocturnal Hemoglobinuria, discusses the direction of continuing research in this area, as well as the potential for the development of management guidelines. It serves as a valuable source of information for both basic scientists and physicians, especially immunologists targeting GPI-anchored proteins and complements, and hematologists specializing in bone marrow failure.
Editors and Affiliations
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Department of Hematology and Ocology, Osaka University Graduate School of Medicine, Suita, Japan
Yuzuru Kanakura
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Immunology Frontier Research Center, Osaka University, Suita, Japan
Taroh Kinoshita
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Dept of Hematology and Ocology, Osaka University Dept of Hematology and Ocology, Suita, Japan
Jun-ichi Nishimura
About the editors
Yuzuru Kanakura, Osaka University, Suita, Japan
Taroh Kinoshita, Osaka University, Suita, Japan
Jun-ichi Nishimura, Osaka University, Suita, Japan
Bibliographic Information
Book Title: Paroxysmal Nocturnal Hemoglobinuria
Book Subtitle: From Bench to Bedside
Editors: Yuzuru Kanakura, Taroh Kinoshita, Jun-ichi Nishimura
DOI: https://doi.org/10.1007/978-4-431-56003-6
Publisher: Springer Tokyo
eBook Packages: Medicine, Medicine (R0)
Copyright Information: Springer Japan KK 2017
Hardcover ISBN: 978-4-431-56001-2Published: 24 January 2017
Softcover ISBN: 978-4-431-56751-6Published: 15 July 2018
eBook ISBN: 978-4-431-56003-6Published: 16 January 2017
Edition Number: 1
Number of Pages: VIII, 358
Number of Illustrations: 25 b/w illustrations, 46 illustrations in colour
Topics: Hematology, Immunology