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Protein Modifications in Pathogenic Dysregulation of Signaling

  • Book
  • © 2015

Overview

Editors:
  1. Jun-ichiro Inoue

    1. Division of Cellular & Molecular Biology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan

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  2. Mutsuhiro Takekawa

    1. The Institute of Medical Science Division of Cell Signaling & Molecular Medicine, The University of Tokyo, Tokyo, Japan

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  • Discusses cutting-edge methodologies and integrated interdisciplinary approaches to the study of post-translational modifications that regulate critical cellular signal pathways

  • Draws together recently identified regulatory mechanisms and biological roles of cell signaling, with recent advances in our understanding of the molecular basis of human diseases

  • Is written by leading experts in the fields of cell signaling and post-translational modifications

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Table of contents (20 chapters)

  1. Front Matter

    Pages i-ix
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  2. Novel Analytical Procedures for Signal Transduction

    1. Front Matter

      Pages 1-1
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    2. Phosphoproteomics-Based Network Analysis of Cancer Cell Signaling Systems

      • Hiroko Kozuka-Hata, Masaaki Oyama
      Pages 3-15

    3. Phos-tag-Based Affinity Chromatography Techniques for Enrichment of the Phosphoproteome

      • Eiji Kinoshita, Emiko Kinoshita-Kikuta, Tohru Koike
      Pages 17-30

    4. Visualization of Intracellular Signaling with Fluorescence Resonance Energy Transfer-Based Biosensors

      • Kazuhiro Aoki
      Pages 31-41

    5. Technology of Wheat Cell-Free-Based Protein Array for Biochemical Analyses of Protein Kinases and Ubiquitin E3 Ligases

      • Hirotaka Takahashi, Keiichirou Nemoto, Ramadan Abdelaziz, Atsushi Uematsu, Tatsuya Sawasaki
      Pages 43-60

  3. Mathematical Simulation of Signal Transduction

    1. Front Matter

      Pages 61-61
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    2. Potential Roles of Spatial Parameters in the Regulation of NF-κB Oscillations, as Revealed by Computer Simulations

      • Daisuke Ohshima, Jun-ichiro Inoue, Kazuhisa Ichikawa
      Pages 63-75

    3. Stochastic Simulation of Stress Granules

      • Daisuke Ohshima, Kyoko Arimoto-Matsuzaki, Taichiro Tomida, Mutsuhiro Takekawa, Kazuhisa Ichikawa
      Pages 77-93

    4. Temporal Coding of Insulin Signaling

      • Hiroyuki Kubota, Shinya Kuroda
      Pages 95-109

  4. Structural Analysis of Signal Transduction

    1. Front Matter

      Pages 111-111
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    2. Structural Biology of Protein Post-transcriptional Modifications and Cellular Signaling

      • Kazuki Kato, Hiroshi Nishimasu, Ryohei Ishii, Osamu Nureki, Ryuichiro Ishitani
      Pages 113-125

    3. Structural Basis for Signal Initiation by TNF and TNFR

      • Teruya Nakamura, Yohei Mukai, Yasuo Tsutsumi, Yuriko Yamagata
      Pages 127-141

    4. Regulation of NF-κB Pathway by Linkage-Specific Ubiquitin-Binding Domains

      • Yusuke Sato
      Pages 143-155

  5. Regulation of Signal Transduction by Post-translational Modifications and Its Pathogenic Dysregulation

    1. Front Matter

      Pages 157-157
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    2. NF-κB Signaling and Lymphoid Malignancies

      • Shoji Yamaoka
      Pages 159-175

    3. Ubiquitination-Mediated NF-κB Regulation in Inflammatory Response

      • Fuminori Tokunaga
      Pages 177-196

    4. NF-κB Signaling in Osteoclastogenesis

      • Yuu Taguchi, Jin Gohda, Jun-ichiro Inoue
      Pages 197-210

    5. Mitogen-Activated Protein Kinase Signaling and Cancer

      • Mutsuhiro Takekawa, Yuji Kubota
      Pages 211-231

    6. Critical Roles of the AKT Substrate Girdin in Disease Initiation and Progression

      • Atsushi Enomoto, Liang Weng, Masahide Takahashi
      Pages 233-250
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Keywords

About this book

This book is devoted to recent advances in analysis of the molecular basis and dynamics of post-translational modifications (PTMs) of proteins for a comprehensive understanding of their key roles in cell signaling networks and diverse biological processes, and their perturbation in a variety of life-threatening diseases such as cancer and inflammatory diseases. The book includes research regarding PTMs and methods of their investigation derived from interdisciplinary collaborations between leading scientists in the fields of molecular, medical, proteomic, structural, and mathematical biology. This book consists of four sections. The first part focuses on recent advances in procedures for analysis of PTMs and cell signaling. The second part is devoted to mathematical simulation of signal transduction pathways and of the formation of protein complexes in living cells. The third part deals with structural and functional analyses of proteins involved in the regulation of PTMs and cell signaling. The fourth part describes cutting-edge findings regarding critical signal transduction pathways and their dysregulation in human diseases. This book is aimed at both established scientists and students in various fields of biology including molecular, cellular, structural, proteomic, and mathematical biology. Readers can access cutting-edge research and methodologies in their own field as well as interdisciplinary research that impacts on their field. The book can function as a reference for pharmaceutical scientists, biomedical researchers, and clinicians for the development of molecular-targeted therapy of human diseases.

Editors and Affiliations

  • Division of Cellular & Molecular Biology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan

    Jun-ichiro Inoue

  • The Institute of Medical Science Division of Cell Signaling & Molecular Medicine, The University of Tokyo, Tokyo, Japan

    Mutsuhiro Takekawa

Bibliographic Information

  • Book Title: Protein Modifications in Pathogenic Dysregulation of Signaling

  • Editors: Jun-ichiro Inoue, Mutsuhiro Takekawa

  • DOI: https://doi.org/10.1007/978-4-431-55561-2

  • Publisher: Springer Tokyo

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Japan 2015

  • Hardcover ISBN: 978-4-431-55560-5Published: 14 September 2015

  • Softcover ISBN: 978-4-431-56253-5Published: 23 October 2016

  • eBook ISBN: 978-4-431-55561-2Published: 02 September 2015

  • Edition Number: 1

  • Number of Pages: IX, 348

  • Number of Illustrations: 40 b/w illustrations, 46 illustrations in colour

  • Topics: Protein Science, Cell Biology, Cancer Research

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