Regulatory Nascent Polypeptides

Editors: Ito, Koreaki (Ed.)

  • Highlights an emerging paradigm: proteins can function during their biosynthesis
  • Is the first book to focus on hitherto unpredicted functions of nascent chains
  • Explains how dynamic translation processes uncover secrets of gene regulation
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  • ISBN 978-4-431-55052-5
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Hardcover $209.00
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  • ISBN 978-4-431-55051-8
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Softcover $209.00
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  • ISBN 978-4-431-56113-2
  • Free shipping for individuals worldwide
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About this book

This book highlights a new paradigm of translation control by regulatory nascent polypeptides, which is integrated into cellular regulatory systems. Translation lies in the hub of the central dogma of biology, in which the genetic information in the forms of 4-letter sentences is translated into 20-letter sentences: sequences of amino acids that constitute proteins, the functional molecules of life. The process involves a huge number of chemical reactions as well as physical movements of the ribosome along a messenger RNA and takes, on average, tens of seconds in prokaryotes and a few minutes in eukaryotes. Detailed knowledge about the progression of translation, called "elongation", only recently started to accumulate. Newly synthesized and growing polypeptides, called nascent polypeptides, can interact with the intra-ribosomal conduit, called the ribosomal exit tunnel, when they have some specific amino acid sequences, called "an arrest sequence". Such interaction leads to a halt in the elongation reaction. Resulting stalling of the ribosome on messenger RNA can affect the secondary structure and/or localization of the message in the cell, consequently leading to biological outputs such as elevation or reduction of a gene product. This book provides a first collection of knowledge focused on regulatory nascent polypeptides, which have been studied recently using diverse organisms including bacteria, plants, and animals. Readers will be impressed by a new paradigm showing that proteins can function even during the course of their biosynthesis and that the ribosome, the "factory" of protein production, interacts with and inspects its products to adjust the speed of completion of each product. Moreover, regulatory nascent polypeptides can sense or monitor physiological states of the cell and modulate its ability to arrest translation. Living organisms use such intricate control mechanisms of translational speed to regulate gene expression. This book will be a useful addition for established scientists while inspiring students and young scientists to gain deeper insights into the processes of expression of genetic information.

About the authors

Koreaki Ito, Senior Research Fellow, Kyoto Sangyo University

Table of contents (17 chapters)

  • Biological Significance of Nascent Polypeptides That Stall the Ribosome

    Ito, Koreaki (et al.)

    Pages 3-20

  • Recent Progress in Ribosome Structure Studies

    Yusupov, Marat

    Pages 23-43

  • Structures of Nascent Polypeptide Chain-Dependent-Stalled Ribosome Complexes

    Wilson, Daniel N. (et al.)

    Pages 45-59

  • Tunnel Vision: Insights from Biochemical and Biophysical Studies

    Deutsch, Carol

    Pages 61-86

  • Nascent Peptide-Induced Signaling from the Exit Tunnel to the Outside of the Ribosome

    Bornemann, Thomas (et al.)

    Pages 87-97

Buy this book

eBook $159.00
price for USA (gross)
  • ISBN 978-4-431-55052-5
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $209.00
price for USA
  • ISBN 978-4-431-55051-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $209.00
price for USA
  • ISBN 978-4-431-56113-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Regulatory Nascent Polypeptides
Editors
  • Koreaki Ito
Copyright
2014
Publisher
Springer Japan
Copyright Holder
Springer Japan
eBook ISBN
978-4-431-55052-5
DOI
10.1007/978-4-431-55052-5
Hardcover ISBN
978-4-431-55051-8
Softcover ISBN
978-4-431-56113-2
Edition Number
1
Number of Pages
IX, 315
Number of Illustrations and Tables
13 b/w illustrations, 62 illustrations in colour
Topics