Sendai Virus Vector

Advantages and Applications

Editors: Nagai, Yoshiyuki (Ed.)

  • Comprehensively reviews the development of SeV vector, a multipurpose cytoplasmic (non-integrating) RNA vector with extremely high performance
  • Describes advanced devices such as transmissibility-deficient or replication-incompetent safer versions and a “footprint (transgene) free” expression system
  • Illustrates diverse applications with high medical impact
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eBook $149.00
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  • ISBN 978-4-431-54556-9
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Hardcover $189.00
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  • ISBN 978-4-431-54555-2
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Softcover $189.00
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  • ISBN 978-4-431-56116-3
  • Free shipping for individuals worldwide
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About this book

Sendai virus (SeV) is not just a mouse pathogen but is evolving into a cutting-edge component of biotechnology. SeV reverse genetics originating from a pure academic need to settle long-held questions in the biology and pathogenicity of nonsegmented negative strand RNA viruses (Mononegavirales) is about to bear the impressive fruit of multipurpose cytoplasmic (non-integrating) RNA vectors. This book brings together in one source the SeV biology revealed by conventional approaches and reverse genetics, the methods to construct the first-generation SeV vector and to generate safer versions, and the applications in medical settings that have left or are about to leave the laboratory bench. The applications, which already are diverse and have high medical impact, include use as vaccine vectors against AIDS and respiratory virus infections, creation of BioKnife to resect malignant tumors, induction of “footprint (transgene) free” pluripotent stem cells, and gene therapy for peripheral arterial disease. These achievements—which are just a few of many examples—were attainable only after rigorously incorporating the rich knowledge of SeV biology that has accumulated during the several decades since the discovery of the virus. Application of SeV vector is certain to expand greatly because of its extremely high performance in transgene expression and its remarkable target cell breadth.

About the authors

Editor
Yoshiyuki Nagai, M.D. Ph.D.
Director, RIKEN Center of Research Network for Infectious Diseases, Japan

Table of contents (8 chapters)

  • Reverse Genetics of Mononegavirales: The Rabies Virus Paradigm

    Conzelmann, Karl-Klaus

    Pages 1-20

  • Sendai Virus Biology and Engineering Leading up to the Development of a Novel Class of Expression Vector

    Nagai, Yoshiyuki (et al.)

    Pages 21-68

  • Concept and Technology Underlying Sendai Virus (SeV) Vector Development

    Iida, Akihiro (et al.)

    Pages 69-89

  • Genome Replication-Incompetent Sendai Virus Vaccine Vector Against Respiratory Viral Infections That Is Capable of Eliciting a Broad Spectrum of Specific Immune Response

    Wiegand, Marian (et al.)

    Pages 91-126

  • Development of Vaccines Using SeV Vectors Against AIDS and Other Infectious Diseases

    Seki, Sayuri (et al.)

    Pages 127-149

Buy this book

eBook $149.00
price for USA (gross)
  • ISBN 978-4-431-54556-9
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $189.00
price for USA
  • ISBN 978-4-431-54555-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $189.00
price for USA
  • ISBN 978-4-431-56116-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Sendai Virus Vector
Book Subtitle
Advantages and Applications
Editors
  • Yoshiyuki Nagai
Copyright
2013
Publisher
Springer Japan
Copyright Holder
Springer Japan
eBook ISBN
978-4-431-54556-9
DOI
10.1007/978-4-431-54556-9
Hardcover ISBN
978-4-431-54555-2
Softcover ISBN
978-4-431-56116-3
Edition Number
1
Number of Pages
XII, 210
Number of Illustrations and Tables
16 b/w illustrations, 17 illustrations in colour
Topics