Cytokine Frontiers

Regulation of Immune Responses in Health and Disease

Editors: Yoshimoto, Takayuki, Yoshimoto, Tomohiro (Eds.)

  • Provides updated information on the roles of cytokines under physiological and pathological conditions to help create strategies for their therapeutic application
  • Presents the most important 15 cytokines, which relate to hot topics recently elucidated in the field of immunology
  • Each chapter deals with one cytokine and is written by experts in the field
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eBook $159.00
price for USA (gross)
  • ISBN 978-4-431-54442-5
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $209.00
price for USA
  • ISBN 978-4-431-54441-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $209.00
price for USA
  • ISBN 978-4-431-56124-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This book guides the reader through the latest research on the cytokine network, covering signaling pathways, control of the immune response, and potential therapeutics. Different cytokines stimulate diverse responses in various phases of inflammation and immunity, including the innate immune response, the generation of effector T cells, and the development of antibodies by the humoral immune system. It is now clear that the pathophysiology of many infectious, autoimmune, allergic, and malignant diseases can be largely explained by which cytokines are induced and subsequently regulate the cellular responses. In clinical medicine, cytokines are involved in a wide spectrum of diseases. This book describes in three parts the properties and roles of 15 key cytokines under physiological and pathological conditions. Part I presents nine cytokines associated with inflammatory disorders, pro-inflammatory cytokines, and the recently identified new helper T (Th) subset: Th17 cells. Part II gives details of three cytokines associated with allergic disorders, including Th2 responses and recently identified types of innate cells. Part III describes three cytokines that are associated with immunological tolerance and anti-inflammation, including regulatory T (Treg) cells, IL-10-producing Treg (Tr1) cells, and inducible IL-35-producing Treg (iTr35) cells. Cytokines are considered to be important as therapeutic targets for specific agonists or antagonists in numerous immune and inflammatory diseases. The ultimate goal of this book is to facilitate the development of therapeutic treatments for such diseases which has been limited by an insufficient understanding of the biology of cytokines and the complicated network that they create.

Table of contents (15 chapters)

  • The Interleukin-1 Family

    Dinarello, Charles A. (et al.)

    Pages 3-51

  • IL-6 and Inflammatory Diseases

    Kamimura, Daisuke (et al.)

    Pages 53-78

  • The Roles of IL-17A and IL-17F in Infection and Inflammatory Disorders

    Ishigame, Harumichi (et al.)

    Pages 79-101

  • IL-18

    Li, Wen (et al.)

    Pages 103-123

  • Interleukin-21: A Pleiotropic Mediator of Immunity and Inflammation with Broad Therapeutic Potential

    Spolski, Rosanne (et al.)

    Pages 125-146

Buy this book

eBook $159.00
price for USA (gross)
  • ISBN 978-4-431-54442-5
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $209.00
price for USA
  • ISBN 978-4-431-54441-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $209.00
price for USA
  • ISBN 978-4-431-56124-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Cytokine Frontiers
Book Subtitle
Regulation of Immune Responses in Health and Disease
Editors
  • Takayuki Yoshimoto
  • Tomohiro Yoshimoto
Copyright
2014
Publisher
Springer Japan
Copyright Holder
Springer Japan
eBook ISBN
978-4-431-54442-5
DOI
10.1007/978-4-431-54442-5
Hardcover ISBN
978-4-431-54441-8
Softcover ISBN
978-4-431-56124-8
Edition Number
1
Number of Pages
XII, 396
Number of Illustrations and Tables
44 illustrations in colour
Topics