TGF-β in Human Disease

Editors: Moustakas, Aristidis, Miyazawa, Keiji (Eds.)

  • Covers the importance of TGF-β in a wide spectrum of human diseases as no previously published book has done
  • Contains up-to-date scientific information written by world experts, reflecting the very rapid evolution of this field
  • Provides a valuable reference for graduate students as well as for experienced researchers in basic and clinical fields
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Buy this book

eBook $159.00
price for USA (gross)
  • ISBN 978-4-431-54409-8
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $209.00
price for USA
  • ISBN 978-4-431-54408-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $209.00
price for USA
  • ISBN 978-4-431-54686-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Transforming growth factor-β (TGF-β) is a secreted polypeptide with multifunctional properties manifested during embryonic development, adult organ physiology, and pathobiology of major diseases, including cancer and fibrotic and cardiovascular diseases. The signaling pathway of TGF-β now is rather well understood. Continuing revelations in the mechanisms of action of TGF-β provide specific mechanistic examples of how human cells lose their controlled function and behave wrongly during the development of diverse diseases. Equally important, however, is the current promise of exploiting the TGF-β pathway in combating human disease. This book comprehensively covers major areas of human disease where the involvement of TGF-β is firmly established. Simultaneously, the book highlights major gaps in knowledge and the future directions of research that can benefit human medical science. The core set of diseases where TGF-β action is well documented and are included in the book are cancer and cardiovascular and fibrotic disorders. The central aim of the book is to stimulate young scientists to enter the prolific TGF-β field and find new solutions to the problems remaining in this area of study. For this purpose the book provides authoritative educational chapters that furnish a good introduction to the field for young doctoral students, postdocs, and clinical fellows. The book also serves as a valuable reference for the aficionados in the field, who can find accessible and well-illustrated material for their teaching and lecturing activities, via which the importance of TGF-β biology is disseminated to the world of science and to the public.

Table of contents (19 chapters)

  • Transforming Growth Factor-β Signaling

    Heldin, Carl-Henrik

    Pages 3-32

  • TGF-β Signaling in Stem Cell Fate Determination

    Li, Zhongwei (et al.)

    Pages 33-58

  • Emerging Roles of TGF-β Co-receptors in Human Disease

    Meyer, Alison E. (et al.)

    Pages 59-89

  • TGF-β in Cancer Stem Cells

    Ikushima, Hiroaki (et al.)

    Pages 93-112

  • TGF-β as Tumor Suppressor: In Vitro Mechanistic Aspects of Growth Inhibition

    Bartholin, Laurent (et al.)

    Pages 113-138

Buy this book

eBook $159.00
price for USA (gross)
  • ISBN 978-4-431-54409-8
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $209.00
price for USA
  • ISBN 978-4-431-54408-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $209.00
price for USA
  • ISBN 978-4-431-54686-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
TGF-β in Human Disease
Editors
  • Aristidis Moustakas
  • Keiji Miyazawa
Copyright
2013
Publisher
Springer Japan
Copyright Holder
Springer Japan
eBook ISBN
978-4-431-54409-8
DOI
10.1007/978-4-431-54409-8
Hardcover ISBN
978-4-431-54408-1
Softcover ISBN
978-4-431-54686-3
Edition Number
1
Number of Pages
VIII, 464
Topics