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  • © 2015

Semaphorins

A Diversity of Emerging Physiological and Pathological Activities

  • Covers the multiple physiological/pathological functions of semaphorins beyond one research field

  • Reviews the recent studies by leading scientists in the field

  • Helps the reader to understand the general concept of semaphorins, which consist of more than 20 family members

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Softcover Book USD 109.99
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Hardcover Book USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
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Table of contents (11 chapters)

  1. Front Matter

    Pages i-viii
  2. Semaphorin Receptors and Their Signaling

    • Manabu Negishi, Izumi Oinuma
    Pages 1-17
  3. Axon Guidance in the Spinal Cord

    • Fumiyasu Imai, Yutaka Yoshida
    Pages 39-63
  4. Structure of Semaphorins and Their Receptors

    • E. Yvonne Jones
    Pages 87-106
  5. Regulation of Angiogenesis and Tumor Progression by Semaphorins

    • Gera Neufeld, Adi D. Sabag, Yelena Mumblat, Tatyana Smolkin, Ofra Kessler
    Pages 107-135
  6. Semaphorins in the Immune System

    • Satoshi Nojima, Atsushi Kumanogoh
    Pages 137-157
  7. Semaphorins in Bone Homeostasis

    • Mikihito Hayashi, Tomoki Nakashima, Hiroshi Takayanagi
    Pages 159-173
  8. Semaphorin in the Heart

    • Masaki Ieda, Keiichi Fukuda
    Pages 175-187
  9. Semaphorins and Neurodegenerative Disorders

    • Tatsusada Okuno, Yuji Nakatsuji
    Pages 189-205
  10. Semaphorin in the Retinal System

    • Toshihiko Toyofuku
    Pages 207-221
  11. Back Matter

    Pages 223-226

About this book

This book presents the current concepts of semaphorin biology. In the early 1990s, semaphorins were originally identified as axon guidance cues that function during neuronal development. However, cumulative findings have clarified that they have diverse functions in many physiological processes, including cardiogenesis, angiogenesis, vasculogenesis, osteoclastogenesis, retinal homeostasis, and immune regulation. Additionally, they have been implicated in the pathogenesis of various human diseases, including tumorigenesis/tumor metastasis, neuroregenerative diseases, retinal degeneration, irregular pulse/sudden death, and immune disorders. Based on this current research background, the book covers the essential state-of-the-art findings for basic scientists in biochemistry, molecular biology, neuroscience, developmental biology, and structural biology, as well as for physicians in neurology, cardiology, oncology, orthopedic surgery, otorhinolaryngology, ophthalmology, allergology, and rheumatology.

Editors and Affiliations

  • Department of Respiratory Medicine Allergy and Rheumatic Diseases, Graduate School of Medicine Osaka University, Suita, Japan

    Atsushi Kumanogoh

Bibliographic Information

  • Book Title: Semaphorins

  • Book Subtitle: A Diversity of Emerging Physiological and Pathological Activities

  • Editors: Atsushi Kumanogoh

  • DOI: https://doi.org/10.1007/978-4-431-54385-5

  • Publisher: Springer Tokyo

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Japan 2015

  • Hardcover ISBN: 978-4-431-54384-8Published: 20 May 2015

  • Softcover ISBN: 978-4-431-56349-5Published: 29 October 2016

  • eBook ISBN: 978-4-431-54385-5Published: 07 May 2015

  • Edition Number: 1

  • Number of Pages: VIII, 226

  • Number of Illustrations: 2 b/w illustrations, 46 illustrations in colour

  • Topics: Immunology, Neurobiology, Cancer Research, Cell Biology, Angiology, Molecular Medicine

Buy it now

Buying options

eBook USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access