Lens Epithelium and Posterior Capsular Opacification

Editors: Saika, Shizuya, Werner, Liliana, Lovicu, Frank J. (Eds.)

  • Describes the pathobiology of posterior capsular opacification and the molecular mechanism of lens epithelial cells as closely interconnected factors
  • Outlines surgical approaches to prevent posterior capsular opacification
  • Comprises chapters written by internationally respected leaders in their respective fields
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  • ISBN 978-4-431-54300-8
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  • Immediate eBook download after purchase
Hardcover $159.00
price for USA
  • ISBN 978-4-431-54299-5
  • Free shipping for individuals worldwide
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Softcover $159.00
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  • Customers within the U.S. and Canada please contact Customer Service at 1-800-777-4643, Latin America please contact us at +1-212-460-1500 (Weekdays 8:30am – 5:30pm ET) to place your order.
  • Due: November 10, 2016
  • ISBN 978-4-431-56140-8
  • Free shipping for individuals worldwide
Rent the ebook  
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About this book

This book is the first to summarize the current knowledge of the cell biology of lens epithelial cells in relation to and in the development of posterior capsular opacification (PCO). PCO remains the most common long-term complication of modern cataract surgery, occurring months or years after cataract surgery, unlike most other complications that tend to arise during or soon after the procedure. Opacification of the posterior capsule appears to be linked to lens epithelial cells that are left behind in the eye during cataract removal. These cells proliferate, migrate across the posterior lens capsule, and undergo changes that result in fibrous or pearl-type opacities in the capsule.

The first section of the text explains the molecular mechanism and biology of lens epithelial cells that lead to the incidence of PCO. In the second part, in addition to a description of the mechanism and pathological condition of PCO, surgical methods and devices for preventing PCO are discussed in detail. Lens Epithelium and Capsular Opacification will benefit not only young clinical residents and junior researchers, but also established faculty in the clinical or basic academic field.

About the authors

Shizuya Saika, M.D. , Ph.D.

Dr. Shizuya Saika is chairman/professor of the Department of Ophthalmology, Wakayama Medical University School of Medicine, Wakayama, Japan. Dr. Saika completed his M.D. in 1988 and his Ph.D. in 1993 from this university. He was also engaged in basic science research in the Department of Ophthalmology, University of Cincinnati School of Medicine, Ohio, USA, in 1998 –1999. He has been engaged in basic science research in wound healing of lens and cornea besides his clinical work, especially of surgeries for cataract, glaucoma and vitreoretinal disorders.

Liliana Werner, M.D., Ph.D.

Liliana Werner, M.D., Ph.D., is a tenured associate professor of ophthalmology and visual sciences and co-director of the Intermountain Ocular Research Center at the John A. Moran Eye Center, University of Utah, Salt Lake City, UT, USA. She has an M.D. degree from Brazil and a Ph.D. degree (biomaterials) from France. Dr. Werner’s research is centered on the interaction between ocular tissues and different intraocular lens designs, materials and surface modifications. These include intraocular lenses implanted after cataract surgery and also phakic lenses for refractive surgery as well as ophthalmic implantable devices in general.

Frank J. Lovicu, Ph.D.

Dr. Frank J. Lovicu is a professor in the School of Medical Sciences, in the Discipline of Anatomy and Histology, Bosch Institute and Save Sight Institute, at the University of Sydney, NSW, Australia. He currently heads the Lens Research Laboratory in Anatomy and Histology, where he primarily studies the role of growth factor signaling in regulating lens cell behavior. His research promotes the understanding of the cellular and molecular processes leading to normal lens development and growth, as well as those leading to cataract. His research findings have the potential for development of new strategies to treat and/or prevent cataract.

Table of contents (24 chapters)

  • From Zygote to Lens: Emergence of the Lens Epithelium

    Robinson, Michael L.

    Pages 3-24

  • Cell Biology of Lens Epithelial Cells

    Bassnett, Steven

    Pages 25-38

  • The Lens Capsule: Synthesis, Remodeling, and MMPs

    West-Mays, Judith A. (et al.)

    Pages 39-57

  • Lens Epithelial Cell Proliferation

    Lovicu, F. J. (et al.)

    Pages 59-80

  • Growth Factor Signaling in Lens Fiber Differentiation

    de Iongh, Robb U. (et al.)

    Pages 81-104

Buy this book

eBook $119.00
price for USA (gross)
  • ISBN 978-4-431-54300-8
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $159.00
price for USA
  • ISBN 978-4-431-54299-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $159.00
price for USA
  • Customers within the U.S. and Canada please contact Customer Service at 1-800-777-4643, Latin America please contact us at +1-212-460-1500 (Weekdays 8:30am – 5:30pm ET) to place your order.
  • Due: November 10, 2016
  • ISBN 978-4-431-56140-8
  • Free shipping for individuals worldwide
Rent the ebook  
  • Rental duration: 1 or 6 month
  • low-cost access
  • online reader with highlighting and note-making option
  • can be used across all devices
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Bibliographic Information

Bibliographic Information
Book Title
Lens Epithelium and Posterior Capsular Opacification
Editors
  • Shizuya Saika
  • Liliana Werner
  • Frank J. Lovicu
Copyright
2014
Publisher
Springer Japan
Copyright Holder
Springer Japan
eBook ISBN
978-4-431-54300-8
DOI
10.1007/978-4-431-54300-8
Hardcover ISBN
978-4-431-54299-5
Softcover ISBN
978-4-431-56140-8
Edition Number
1
Number of Pages
XVII, 424
Number of Illustrations and Tables
35 b/w illustrations, 140 illustrations in colour
Topics