Progress in Drug Research

Epigenetics and Disease

Pharmaceutical Opportunities

Editors: Gasser, Susan M., Li, En (Eds.)

  • Discusses new approaches to pharmaceutical intervention
  • Includes new findings from stem cell research
  • With numerous illustrations
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eBook $229.00
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  • ISBN 978-3-7643-8989-5
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Softcover $289.00
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  • ISBN 978-3-0348-0305-2
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About this book

Epigenetics has emerged recently as an important area of molecular biological studies. Epigenetic modifications lead to potentially heritable but reversible alterations in the expression of genes that determine cell fate. Epigenetic misregulation is thus often linked to degenerative diseases, cancer and neuronal disorders. Recent biomedical interest in this regulatory system stems from the fact that epigenetic, in contrast to genetic, alterations are in principle amenable to pharmacological intervention. A few epigenetically active drugs, for example histone deacetylase inhibitors (HDACi) and DNA methyltransferase (DNMT) inhibitors, have been approved by FDA for treatment of cancers such as CTCL, MDS, and AML. This volume explores the scientific background for clinical applications of epigenetically active drugs. Included are descriptions of epigenetic controls over gene expression, the post-transcriptional silencing of genes by RNA interference (RNAi) and microRNAs, as well as new findings from stem cell research which are relevant to pharmacological applications.

Table of contents (13 chapters)

  • DNA Methylation and Cancer

    Taberlay, Phillippa C. (et al.)

    Pages 1-23

  • Genome-Wide Epigenetic Modifications in Cancer

    Park, Yoon Jung (et al.)

    Pages 25-49

  • DNA Repair and the Control of DNA Methylation

    Schär, Primo (et al.)

    Pages 51-68

  • Errors in Erasure: Links Between Histone Lysine Methylation Removal and Disease

    Duncan, Elizabeth M. (et al.)

    Pages 69-90

  • Histone Modifications in Cancer Biology and Prognosis

    Kurdistani, Siavash K.

    Pages 91-106

Buy this book

eBook $229.00
price for USA (gross)
  • ISBN 978-3-7643-8989-5
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $289.00
price for USA
  • ISBN 978-3-7643-8988-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $289.00
price for USA
  • ISBN 978-3-0348-0305-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Epigenetics and Disease
Book Subtitle
Pharmaceutical Opportunities
Editors
  • Susan M. Gasser
  • En Li
Series Title
Progress in Drug Research
Series Volume
67
Copyright
2011
Publisher
Springer Basel
Copyright Holder
Springer Basel AG
eBook ISBN
978-3-7643-8989-5
DOI
10.1007/978-3-7643-8989-5
Hardcover ISBN
978-3-7643-8988-8
Softcover ISBN
978-3-0348-0305-2
Series ISSN
0071-786X
Edition Number
1
Number of Pages
X, 270
Topics