Milestones in Drug Therapy

Bortezomib in the Treatment of Multiple Myeloma

Editors: Ghobrial, Irene M., Richardson, Paul G., Anderson, Kenneth C. (Eds.)

  • Contemporary monograph on Bortezomib and the proteasome discovery from the lab to the clinic
  • A valuable source of information for researchers and clinicians from the fields of oncology and pharmacology
  • Depicts the biochemical background of the drug action
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eBook $179.00
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  • ISBN 978-3-7643-8948-2
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  • Immediate eBook download after purchase
Hardcover $229.00
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  • ISBN 978-3-7643-8947-5
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About this book

Multiple Myeloma (MM) is the second most common type of blood cancer, resulting from an overproduction of cancerous infection-fighting white blood cells, known as plasma cells. Plasma cells are a crucial part of the immune system responsible for the production of antibodies. Bortezomib is a promising anticancer drug targeting the proteasome. This proteasome inhibitor induces cell stress and apoptosis in the cancer cells. While multiple mechanisms are likely to be involved, proteasome inhibition may prevent the degradation of pro-apoptotic factors, permitting activation of programmed cell death in neoplastic cells dependent upon the suppression of proapoptotic pathways. This monograph on bortezomib is a valuable source of information for researchers and clinicians from the fields of oncology and pharmacology, working either in academia or the pharmaceutical industry.

Table of contents (11 chapters)

  • Bortezomib’s Scientific Origins and Its Tortuous Path to the Clinic

    Goldberg, Alfred L.

    Pages 1-27

  • Preclinical Activities of Bortezomib in MM, the Bone Marrow Microenvironment and Pharmacogenomics

    Hideshima, Teru (et al.)

    Pages 29-42

  • Bortezomib and Osteoclasts and Osteoblasts

    Krauze, Michal T. (et al.)

    Pages 43-52

  • Bortezomib in the Upfront Treatment of Multiple Myeloma

    Miguel, Jesús F. San (et al.)

    Pages 53-68

  • The Use of Bortezomib in Autologous Transplantation for Multiple Myeloma

    Langston, Amelia A. (et al.)

    Pages 69-77

Buy this book

eBook $179.00
price for USA (gross)
  • ISBN 978-3-7643-8948-2
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $229.00
price for USA
  • ISBN 978-3-7643-8947-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Rent the ebook  
  • Rental duration: 1 or 6 month
  • low-cost access
  • online reader with highlighting and note-making option
  • can be used across all devices
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Bibliographic Information

Bibliographic Information
Book Title
Bortezomib in the Treatment of Multiple Myeloma
Editors
  • Irene M. Ghobrial
  • Paul G. Richardson
  • Kenneth C. Anderson
Series Title
Milestones in Drug Therapy
Copyright
2011
Publisher
Springer Basel
Copyright Holder
Springer Basel AG
eBook ISBN
978-3-7643-8948-2
DOI
10.1007/978-3-7643-8948-2
Hardcover ISBN
978-3-7643-8947-5
Series ISSN
2296-6056
Edition Number
1
Number of Pages
VIII, 180
Topics