Overview
- Covers all relevant aspects of anti-influenza virus drug discovery
- Contributions by international leading scientists
- A valuable source of information for researchers, clinicians and the pharmaceutical industry
- Includes supplementary material: sn.pub/extras
Part of the book series: Milestones in Drug Therapy (MDT)
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Table of contents (8 chapters)
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Front Matter
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Back Matter
Keywords
About this book
Influenza continues to be an ongoing problem despite the existence of vaccines and drugs. Disease outbreaks can occur relatively quickly as witnessed with the recent emergence of the influenza virus A/H1N1 pandemic. The development of new anti-influenza drugs is thus a major challenge.
This volume describes all aspects of the virus structure and function relevant to infection. The focus is on drug discovery of inhibitors to the enzyme sialidase, which plays a key role in the infectious lifecycle of the virus. Following an overview of the influenza virus, the haemagglutinin, the interactions with the cell receptors and the enzymology of virus sialidase, recent results in drug design are presented. These include a full coverage of the design, synthesis and evaluation of carbohydrate as well as non-carbohydrate influenza virus sialidase inhibitors. Further reviews of the clinical experience with influenza virus sialidase inhibitors and of the development of resistance to these inhibitor drugs complement the topic.
Editors and Affiliations
Bibliographic Information
Book Title: Influenza Virus Sialidase - A Drug Discovery Target
Editors: Mark Itzstein
Series Title: Milestones in Drug Therapy
DOI: https://doi.org/10.1007/978-3-7643-8927-7
Publisher: Springer Basel
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Basel AG 2012
Hardcover ISBN: 978-3-7643-8926-0Published: 15 September 2011
Softcover ISBN: 978-3-0348-0779-1Published: 21 October 2014
eBook ISBN: 978-3-7643-8927-7Published: 01 September 2011
Series ISSN: 2296-6056
Series E-ISSN: 2296-6064
Edition Number: 1
Number of Pages: IX, 178
Topics: Pharmacology/Toxicology, Infectious Diseases, Virology, Immunology