Milestones in Drug Therapy

Influenza Virus Sialidase - A Drug Discovery Target

Editors: von Itzstein, Mark (Ed.)

  • Covers all relevant aspects of anti-influenza virus drug discovery
  • Contributions by international leading scientists
  • A valuable source of information for researchers, clinicians and the pharmaceutical industry
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  • ISBN 978-3-7643-8927-7
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  • ISBN 978-3-7643-8926-0
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Softcover $259.00
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About this book

Influenza continues to be an ongoing problem despite the existence of vaccines and drugs. Disease outbreaks can occur relatively quickly as witnessed with the recent emergence of the influenza virus A/H1N1 pandemic. The development of new anti-influenza drugs is thus a major challenge.

This volume describes all aspects of the virus structure and function relevant to infection. The focus is on drug discovery of inhibitors to the enzyme sialidase, which plays a key role in the infectious lifecycle of the virus. Following an overview of the influenza virus, the haemagglutinin, the interactions with the cell receptors and the enzymology of virus sialidase, recent results in drug design are presented. These include a full coverage of the design, synthesis and evaluation of carbohydrate as well as non-carbohydrate influenza virus sialidase inhibitors. Further reviews of the clinical experience with influenza virus sialidase inhibitors and of the development of resistance to these inhibitor drugs complement the topic.

Table of contents (8 chapters)

  • Influenza Virology

    Klenk, Hans Dieter

    Pages 1-29

  • Investigating the Interaction Between Influenza and Sialic Acid: Making and Breaking the Link

    Nicholls, John M. (et al.)

    Pages 31-45

  • Enzymology of Influenza Virus Sialidase

    Chan, Jefferson (et al.)

    Pages 47-66

  • Influenza Virus Sialidase and Structure-Based Drug Design

    Dyason, Jeffrey C. (et al.)

    Pages 67-75

  • The Development of Carbohydrate-Based Influenza Virus Sialidase Inhibitors

    Thomson, Robin (et al.)

    Pages 77-104

Buy this book

eBook $199.00
price for USA (gross)
  • ISBN 978-3-7643-8927-7
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $259.00
price for USA
  • ISBN 978-3-7643-8926-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $259.00
price for USA
  • ISBN 978-3-0348-0779-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Influenza Virus Sialidase - A Drug Discovery Target
Editors
  • Mark von Itzstein
Series Title
Milestones in Drug Therapy
Copyright
2012
Publisher
Springer Basel
Copyright Holder
Springer Basel AG
eBook ISBN
978-3-7643-8927-7
DOI
10.1007/978-3-7643-8927-7
Hardcover ISBN
978-3-7643-8926-0
Softcover ISBN
978-3-0348-0779-1
Series ISSN
2296-6056
Edition Number
1
Number of Pages
IX, 178
Topics