Progress in Inflammation Research

Th 17 Cells: Role in Inflammation and Autoimmune Disease

Editors: Quesniaux, Valérie, Ryffel, Bernhard, Di Padova, Franco (Eds.)

  • A topical volume describing in detail the Th17 cell population
  • Several new therapeutic targets are discussed in this context
  • International authorship
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eBook $149.00
price for USA (gross)
  • ISBN 978-3-7643-8681-8
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About this book

With the recent definition of the Th17 cell subset, a new paradigm in innate and adaptive immunity has been established. This book describes the function of the Th17 cell subset and its prevalent role in many inflammatory and autoimmune diseases. The mechanism by which this T cell subset is generated and maintained shows specific differences between mice and man which are reviewed. One characteristic of Th17 cells is to secrete specific and unique cytokines such as IL-17A, IL-17F and IL-22; their functions are described in detail. These cytokines have acquired a prevalent role in many pathological conditions in animal models and in humans. Targeting these cytokines as well as the generation of Th17 cells may open new ways to treat many autoimmune diseases. The role of Th17 in infectious conditions is also addressed.

Reviews

From the reviews:

“This very interesting volume contains 18 reviews grouped in five chapters and presents the accumulated knowledge related to the IL-17 cytokines, a novel family of cytokines that defines a new effector T cell, the Th17 cell, and extends the Th1-Th2 paradigm. … This multi-authors volume is an exciting and rewarding reading for scientists and medical doctors exploring novel mechanisms of inflammation and therapy.” (Mihaela Trif, Romanian Journal of Biochemistry, Vol. 47 (2), 2010)

Table of contents (19 chapters)

  • Introduction

    Padova, Franco (et al.)

    Pages 1-9

  • IL-22 and IL-17: Common and different properties

    Sabat, Robert (et al.)

    Pages 13-38

  • Other sources of IL-17: Invariant natural killer T cells

    Miche, Marie-Laure (et al.)

    Pages 39-48

  • Contributions of IL-22 to Th17 responses: Repairing and protecting peripheral tissues

    Renauld, Jean-Christophe (et al.)

    Pages 49-60

  • Retinoic acid in mucosal immune-regulation

    Mucida, Daniel (et al.)

    Pages 61-68

Buy this book

eBook $149.00
price for USA (gross)
  • ISBN 978-3-7643-8681-8
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
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Bibliographic Information

Bibliographic Information
Book Title
Th 17 Cells: Role in Inflammation and Autoimmune Disease
Editors
  • Valérie Quesniaux
  • Bernhard Ryffel
  • Franco Di Padova
Series Title
Progress in Inflammation Research
Copyright
2009
Publisher
Birkhäuser Basel
Copyright Holder
Birkhäuser Basel
eBook ISBN
978-3-7643-8681-8
DOI
10.1007/978-3-7643-8681-8
Edition Number
1
Number of Pages
XII, 244
Number of Illustrations and Tables
20 b/w illustrations
Topics