Milestones in Drug Therapy

PEGylated Protein Drugs: Basic Science and Clinical Applications

Editors: Veronese, Francesco M. (Ed.)

  • Vast information on PEG and PEG-conjugates collected in one book
  • Competent authorship from academia and industry assures comprehensive information
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Hardcover $259.00
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About this book

PEGylated Protein Drugs: Basic Science and Clinical Applications describes the basic technologies and the major results obtained with the PEGylation technique, the covalent binding to proteins, peptides and small organic molecules of the hydrophilic and biocompatible polymer poly(ethylene glycol) to improve their therapeutic efficacy.

The book results from the collaboration of recognized experts from academia and industry, working on various aspects of the PEGylation technology. The first chapters provide general information on the physicochemical, pharmacokinetic, immunogenic and toxicological properties of PEG and PEG-conjugates. The classical and more advanced chemical strategies for linking PEG to protein drugs are described as well as novel enzyme-catalysed approaches. Further chapters are devoted to important PEGylated products, namely PEG conjugates of enzymes, cytokines, antibodies or synthetic organic molecules already on the market or in an advanced state of clinical experimentation. Guidelines for the approval by the Health Agencies of these new nanomedicines are also reported as a last chapter.

Therefore, this book may be a unique instrument for a thorough review of the strategy, advantages and limitations of all aspects of drug PEGylation as well as a stimulation for researchers to develop new exploitations of this technology. It is of interest to physicians, biochemists, pharmacologists and chemists.

Reviews

From the reviews:

“The volume is dedicated to the recent advances on PEGylation and PEGylated compunds. It represents an excellent update in the evolution of this field, from nanoscience to clinical applications. The book provides an excellent update in this rapidly evolving field. … This valuable volume which will spark the interest of both researchers and clinicians contributes to a better understanding of polymer therapeutics.” (Magdalena Moisei, Romanian Journal of Biochemistry, Vol. 47 (2), 2010)

Table of contents (16 chapters)

  • Preface PEGylated protein conjugates: A new class of therapeutics for the 21st century

    Duncan, Ruth (et al.)

    Pages 1-9

  • Protein PEGylation, basic science and biological applications

    Veronese, Francesco M. (et al.)

    Pages 11-31

  • Reactive PEGs for protein conjugation

    Bonora, Gian Maria (et al.)

    Pages 33-45

  • Rebridging disulphides: site-specific PEGylation by sequential bis-alkylation

    Choi, Ji-Won (et al.)

    Pages 47-73

  • Enzymatic techniques for PEGylation of biopharmaceuticals

    Sergi, Mauro (et al.)

    Pages 75-88

Buy this book

eBook $199.00
price for USA (gross)
  • ISBN 978-3-7643-8679-5
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $259.00
price for USA
  • ISBN 978-3-7643-8678-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
PEGylated Protein Drugs: Basic Science and Clinical Applications
Editors
  • Francesco M. Veronese
Series Title
Milestones in Drug Therapy
Copyright
2009
Publisher
Birkhäuser Basel
Copyright Holder
Birkhäuser Basel
eBook ISBN
978-3-7643-8679-5
DOI
10.1007/978-3-7643-8679-5
Hardcover ISBN
978-3-7643-8678-8
Series ISSN
2296-6056
Edition Number
1
Number of Pages
IX, 290
Topics