Progress in Drug Research

Imaging in Drug Discovery and Early Clinical Trials

Editors: Rudin, Markus (Ed.)

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About this book

The impact of genomics on biomedical research and the development of efficient technology platforms allowing for highly parallel compound synthesis and screening procedures have led to a major paradigm shift in drug discovery and development. Efficient tools for the selection and validation of drug targets both at the preclinical and clinical level are required. Non-invasive imaging and in particular molecular imaging methods are becoming essential technologies to support drug discovery and dvelopment. Imaging provides structural, functional, metabolic and molecular readouts that are being applied to characterize a disease phenotype (diagnosis), to elucidate molecular mechanisms involved, to evaluate drug efficacy and safety, and to identify potential biomarkers of the drug's mechanism-of-action, efficacy and safety. Non-invasive imaging techniques constitute a bridge between preclinical and clinical drug evaluation.
In this monograph the contribution of imaging modalities to the various stages of drug discovery and development, from early target validation to their use in clinical development programs, is described. Chapters are devoted to the description of the drug discovery process as such, to the various imaging modalities being used both preclinically and clinically, to applications of imaging during the optimization of a lead compound (addressing issues such as bioavailability and efficacy) and during the drug safety evaluation. A chapter describes imaging biomarkers, their development, advantages and the potential pitfalls associated with their use. In the translation of imaging tools from animals to man regulatory issues have to be addressed, which are dealt with in a separate section.
The monograph provides a comprehensive overview on the role of imaging in drug discovery today and discusses major developments and trends both with regard to technologies and applications.

Table of contents (7 chapters)

  • The drug discovery process

    Paul L. Herrling

    Pages 1-14

  • Imaging modalities: principles and information content

    Tobias Schaeffter

    Pages 15-81

  • Magnetic resonance and fluorescence based molecular imaging technologies

    David Sosnovik, Ralph Weissleder

    Pages 83-115

  • Studying molecular and cellular processes in the intact organism

    Olivier Gheysens, Sanjiv S. Gambhir

    Pages 117-150

  • Evaluation of drug candidates: Efficacy readouts during lead optimization

    Markus Rudin, Nicolau Beckmann, Martin Rausch

    Pages 185-255

Buy this book

eBook $89.00
price for USA (gross)
  • ISBN 978-3-7643-7426-6
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $119.00
price for USA
  • ISBN 978-3-7643-7780-9
  • Free shipping for individuals worldwide
  • This title is currently reprinting. You can pre-order your copy now.
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Bibliographic Information

Bibliographic Information
Book Title
Imaging in Drug Discovery and Early Clinical Trials
Editors
  • Markus Rudin
Series Title
Progress in Drug Research
Series Volume
62
Copyright
2005
Publisher
Birkhäuser Basel
Copyright Holder
Birkhäuser Basel
eBook ISBN
978-3-7643-7426-6
DOI
10.1007/3-7643-7426-8
Softcover ISBN
978-3-7643-7780-9
Series ISSN
0071-786X
Edition Number
1
Number of Pages
X, 392
Number of Illustrations and Tables
61 b/w illustrations, 26 illustrations in colour
Topics