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COX-2 Inhibitors

  • Book
  • © 2004

Overview

Editors:
  1. Michel Pairet

    1. Department of Pulmonary Research, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach a. d. Riss, Germany

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  2. Joanne Ryn

    1. Department Drug Discovery Support, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach a. d. Riss, Germany

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  • GIVES BACKGROUND INFORMATION ABOUT THE DISCOVERY OF COX-2 PROVIDES AN EXCELLENT OVERVIEW OF THE PHARMACOLOGY AND TOXICOLOGY OF COX-2 AGENTS PROVIDES INFORMATION ABOUT EFFECTS OF COX-2
  • ON THE CARDIOVASCULAR SYSTEM, LUNGS, KIDNEY, ULCERS AND REPRODUCTION
  • TARGETS MAJOR BIOLOGICAL SYSTEMS WHERE COX-2 INHIBITORS HAVE THE POTENTIAL TO BE DIFFERENT FROM NON-SELECTIVE INHIBITORS AND REVIEWS EVIDENCE FOR AND AGAINST THIS
  • Includes supplementary material: sn.pub/extras

Part of the book series: Milestones in Drug Therapy (MDT)

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Table of contents (11 chapters)

  1. Front Matter

    Pages I-X
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  2. The discovery of COX-2

    • Regina M. Botting, Jack H. Botting
    Pages 1-13

  3. Structural diversity of selective COX-2 inhibitors

    • Lawrence J. Marnett, Amit S. Kalgutkar
    Pages 15-40

  4. The molecular and biological basis for COX-2 selectivity

    • Guenter Trummlitz, Joanne van Ryn, Timothy D. Warner
    Pages 41-65

  5. Pharmacology and toxicology of COX-2 inhibitors

    • K. D. Rainsford
    Pages 67-131

  6. Efficacy and gastrointestinal safety of selective COX-2 inhibitors

    • Frank Degner
    Pages 133-148

  7. Role of COX-2 in ulcers and ulcer healing

    • Joanne van Ryn, Michel Pairet
    Pages 149-160

  8. COX-2 and the cardiovascular system

    • Rahul Nayak, Brendan F. McAdam
    Pages 161-178

  9. Effects on the kidney: role of COX-2 inhibitors

    • Dirk O. Stichtenoth
    Pages 179-194

  10. Effects on the lungs: role of COX-2 inhibitors

    • R. Stokes Peebles Jr., Koichi Hashimoto
    Pages 195-212

  11. Reproduction: role of COX-2 and its inhibition

    • Aarthi R. Mohan, Phillip R. Bennett
    Pages 213-225

  12. COX-2 in cancer

    • Kirsi Saukkonen, Christianne J. Buskens, Anna Sivula, Bastiaan P. van Rees, Tiina-Liisa Erkinheimo, Johanna Rintahaka et al.
    Pages 227-243

  13. Back Matter

    Pages 245-250
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Keywords

About this book

COX-2 inhibitors are important drugs with analgesic and anti-inflammatory effects. The discovery of COX-2, the evolution of drug development in this field and the implications of these developments in patient therapy are topics of this volume. This book presents both pre-clinical and clinical information and is important for clinicians interested in the latest information about this class of drugs, for researchers and for students in the field.

Editors and Affiliations

  • Department of Pulmonary Research, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach a. d. Riss, Germany

    Michel Pairet

  • Department Drug Discovery Support, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach a. d. Riss, Germany

    Joanne Ryn

Bibliographic Information

  • Book Title: COX-2 Inhibitors

  • Editors: Michel Pairet, Joanne Ryn

  • Series Title: Milestones in Drug Therapy

  • DOI: https://doi.org/10.1007/978-3-0348-7879-1

  • Publisher: Birkhäuser Basel

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Basel AG 2004

  • Hardcover ISBN: 978-3-7643-6901-9Published: 29 March 2004

  • Softcover ISBN: 978-3-0348-9607-8Published: 05 November 2012

  • eBook ISBN: 978-3-0348-7879-1Published: 06 December 2012

  • Series ISSN: 2296-6056

  • Series E-ISSN: 2296-6064

  • Edition Number: 1

  • Number of Pages: X, 250

  • Topics: Pharmacology/Toxicology, Cell Biology, Immunology, Molecular Medicine, Pain Medicine

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