Introduction to Computational Biology

An Evolutionary Approach

Authors: Haubold, Bernhard, Wiehe, Thomas

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About this Textbook

Molecular biology has changed dramatically over the past two decades. Until the early 1990s genes were studied one at a time by small teams of researchers; today entire genomes are sequenced by internationally collaborating laboratories. In the bygone gene-centered era the accumulation of data was the rate-limiting step in research. Now that step is often data interpretation. This is increasingly dependent on computational methods and as a consequence, computational biology has emerged in the past decade as a new subdiscipline of biology.

This introduction to computational biology is centered on the analysis of molecular sequence data. There are two closely connected aspects to biological sequences: (i) their relative position in the space of all other sequences, and (ii) their movement through this sequence space in evolutionary time. Accordingly, the first part of the book deals with classical methods of sequence analysis: pairwise alignment, exact string matching, multiple alignment, and hidden Markov models. In the second part evolutionary time takes center stage and phylogenetic reconstruction, the analysis of sequence variation, and the dynamics of genes in populations are explained in detail. In addition, the book contains a computer program with a graphical user interface that allows the reader to experiment with a number of key concepts developed by the authors.

Introduction to Computational Biology is intended for students enrolled in courses in computational biology or bioinformatics as well as for molecular biologists, mathematicians, and computer scientists.

Bernhard Haubold is associate professor at the University of Applied Sciences, Weihenstephan, Germany. Thomas Wiehe is associate professor at the University of Cologne, Germany.

Reviews

From the reviews: “Haubold and Weihe is precisely addressed to this increasingly large circle of people using sequences … an introduction to the computational aspects of genomics and the interpretation of sequence biological data. … Each chapter ends with a small section of interesting exercises and accompanying answers … . These make the book very useful for students in bioinformatics but also for researchers and students in molecular biology, genetics, medicine or at the other end students in computer sciences or mathematics interested in molecular biology.” (Andrei Petrescu, Romanian Journal of Biochemistry, Vol. 47 (1), 2010)

Table of contents (2 chapters)

Buy this book

eBook $54.99
price for USA (gross)
  • ISBN 978-3-7643-7387-0
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $69.95
price for USA
  • ISBN 978-3-7643-6700-8
  • book with CD
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Introduction to Computational Biology
Book Subtitle
An Evolutionary Approach
Authors
Copyright
2006
Publisher
Birkhäuser Basel
Copyright Holder
Birkhäuser Basel
eBook ISBN
978-3-7643-7387-0
DOI
10.1007/3-7643-7387-3
Hardcover ISBN
978-3-7643-6700-8
Edition Number
1
Number of Pages
XIV, 328
Topics