Experientia Supplementum

Mechanisms of Angiogenesis

Editors: Clauss, Matthias, Breier, Georg (Eds.)

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About this book

Is it advisable to go back from bedside to the bench? During the last decade, few topics encountered such a broad interest in bio- gy and medicine as angiogenesis. The amazing ability of the body to restore blood flow by induction of blood vessel growth as part of an adaptive process has alarmed physicians dealing with diseases in which angiogenesis is either exaggerated (as in tumors) or too slow (as in ischemic diseases of heart and brain). Not surprisingly, pro- and antiangiogenic strategies have found their way into clinical trials. For instance, for the USA, the NIH website in early 2004 displayed 38 clinical studies involving either pro- or antiangiogenic th- apies. Given the expected overwhelming wealth of clinical data, the question may be asked whether further exploration of biological mechanisms is required or whether results from the bedside are instructive enough to proceed. This question depends also on the progress of pro- and antiangiogenic clinical trials. In the following, I give a short overview about some of the progress that has been made in this field. Since Judah Folkman proposed antiangiogenic tumor therapy thirty years ago, it has become increasingly evident that agents which interfere with blood vessel formation also block tumor progression. Accordingly, antiangiogenic therapy has gained much attention as a potential adjunct to conventional c- cer therapy.

Table of contents (4 chapters)

  • How do endothelial cells orientate?

    Holger Gerhardt, Christer Betsholtz

    Pages 3-15

  • Role of pericytes in vascular morphogenesis

    Christer Betsholtz, Per Lindblom, Holger Gerhardt

    Pages 115-125

  • The role of VEGF in the regulation of physiological and pathological angiogenesis

    Napoleone Ferrara

    Pages 209-231

  • The anti-inflammatory actions of angiopoietin-1

    Gavin Thurston, John S. Rudge, Ella Ioffe, et al.

    Pages 233-245

Buy this book

eBook $189.00
price for USA (gross)
  • ISBN 978-3-7643-7311-5
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $239.00
price for USA
  • ISBN 978-3-7643-6459-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Mechanisms of Angiogenesis
Editors
  • Matthias Clauss
  • Georg Breier
Series Title
Experientia Supplementum
Series Volume
94
Copyright
2005
Publisher
Birkhäuser Basel
Copyright Holder
Birkhäuser Basel
eBook ISBN
978-3-7643-7311-5
DOI
10.1007/b137088
Hardcover ISBN
978-3-7643-6459-5
Series ISSN
1023-294X
Edition Number
1
Number of Pages
XIV, 324
Topics