Milestones in Drug Therapy

Calcium Channel Blockers

Authors: Godfraind, Theophile

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About this book

The drugs named calcium channel blockers (CCBs) were initially termed cal­ cium antagonists (see Chapter 1). They are also designated as calcium entry blockers (CEBs), calcium blockers, calcium channel antagonists, calcium channel inhibitors (and in French anticalciques). As this is reported in several chapters of this book, their main effect is a blockade of calcium entry into cells through voltage operated calcium channels (VOCCs). Chemically related drugs, such as Bay K 8644, exert the opposite effect by increasing the proba­ bility of calcium channel opening. One of the subcommittees of the Nomenclature Committee (NC-IUPAR) of the International Union of Pharmacology has been devoted to the classification of calcium channels and the site of action of drugs modifying channel function. The members of this Committee are noted for their significant contribution to the field (Tab. 1). A report has been published in 1992 in Pharmacological Reviews [3]. A list of criteria was approved for the identification of distinct drug binding 2 sites on Ca + channels. It included: (a) the demonstration of a stereoselective binding site supported by drug interaction studies (competition with other drugs, non-competitive interactions with other sites, reversal of inhibitory effects by channel activators); (b) demonstration of the electrophysiologieal effects of the drug and selectivity of action compared to other sites; (c) deter­ mination of the affinity for the type and subtype of ion channel. These criteria have identified different classes of Ca antagonists (see Chapter 2).

Table of contents (10 chapters)

  • Historical perspective: from early steps on calcium research to the identification of calcium antagonist prototypes and of the signaling functions of Ca2+

    Godfraind, Théophile

    Pages 1-9

  • Calcium channel blockers and calcium channels

    Ertel, Eric (et al.)

    Pages 11-80

  • The action of calcium antagonists on Ca2+ movements in isolated vessels

    Godfraind, Théophile

    Pages 81-112

  • The tissue selectivity of calcium antagonists

    Godfraind, Théophile

    Pages 113-129

  • Acute haemodynamic effects of calcium channel blockers

    Godfraind, Théophile

    Pages 131-149

Buy this book

eBook $209.00
price for USA (gross)
  • ISBN 978-3-0348-7859-3
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $299.00
price for USA
  • ISBN 978-3-7643-6435-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $269.00
price for USA
  • ISBN 978-3-0348-9599-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Calcium Channel Blockers
Authors
Series Title
Milestones in Drug Therapy
Copyright
2004
Publisher
Birkhäuser Basel
Copyright Holder
Springer Basel AG
eBook ISBN
978-3-0348-7859-3
DOI
10.1007/978-3-0348-7859-3
Hardcover ISBN
978-3-7643-6435-9
Softcover ISBN
978-3-0348-9599-6
Series ISSN
2296-6056
Edition Number
1
Number of Pages
XIV, 262
Topics