Hydrogen Sulfide and its Therapeutic Applications

Editors: Kimura, Hideo (Ed.)

  • Gives a broad overview to the topic from chemical and biochemical basics to therapeutic application
  • First volume on the topic with interdisciplinary scope
  • Respective topics discussed by experts in basic science and clinical application
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eBook $159.00
price for USA (gross)
  • ISBN 978-3-7091-1550-3
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  • Immediate eBook download after purchase
Hardcover $209.00
price for USA
  • ISBN 978-3-7091-1549-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $209.00
price for USA
  • ISBN 978-3-7091-1974-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

The metabolism of sulfur especially by sulfurtransferases had been intensively studied in mid 1900’s.  Three enzymes, cystathionine β–synthase (CBS), cystathionine γ–lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (3MST) were found to have the capacity to produce H2S in vitro.  However, H2S was recognized simply as a by-product of the metabolic pathways or as a marker for evaluating the activity of enzymes rather than as a physiological active molecule.   In the late 1980’s relatively high concentrations of sulfide were measured in the brain that led to the successive studies of identifying the physiological functions of H2S.  Recently, the steady-state concentrations of H2S have been re-evaluated and found to be much less than that initially measured.  However, despite these differences, such re-evaluations served to further confirm the existence of H2S in mammalian tissues.  H2S is produced in almost every organ and plays various roles such as neuromodulation, vasodilation, insulin release, inflammation, angiogenesis and cytoprotection. The unregulated production of H2S and improper responses of target molecules are involved in the pathogenesis of various diseases.  This book focuses on these topics as well as on the recent progress in the biology and the therapeutic development of this molecule.

Table of contents (9 chapters)

  • Enzymology of Hydrogen Sulfide Turnover

    Motl, Nicole (et al.)

    Pages 1-35

  • Hydrogen Sulfide as an Oxygen Sensor

    Olson, Kenneth R.

    Pages 37-62

  • Multiple Roles of H2S in Inflammation: A New Class of Therapeutics?

    Li, Ling (et al.)

    Pages 63-82

  • Signaling Mechanisms Underlying the Hydrogen Sulfide Effects: Identification of Hydrogen Sulfide “Receptors”

    Zhu, Yi-Chun

    Pages 83-107

  • Hydrogen Sulfide: Its Production, Release and Functions

    Flannigan, Kyle L. (et al.)

    Pages 109-125

Buy this book

eBook $159.00
price for USA (gross)
  • ISBN 978-3-7091-1550-3
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $209.00
price for USA
  • ISBN 978-3-7091-1549-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $209.00
price for USA
  • ISBN 978-3-7091-1974-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Hydrogen Sulfide and its Therapeutic Applications
Editors
  • Hideo Kimura
Copyright
2013
Publisher
Springer-Verlag Wien
Copyright Holder
Springer-Verlag Wien
eBook ISBN
978-3-7091-1550-3
DOI
10.1007/978-3-7091-1550-3
Hardcover ISBN
978-3-7091-1549-7
Softcover ISBN
978-3-7091-1974-7
Edition Number
1
Number of Pages
IX, 207
Number of Illustrations and Tables
16 b/w illustrations, 23 illustrations in colour
Topics