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Sphingolipids in Disease

  • Book
  • © 2013

Overview

Editors:
  1. Erich Gulbins

    1. , Department of Molecular Biology, University of Duisburg-Essen, Essen, Germany

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    You can also search for this editor in PubMed   Google Scholar

  2. Irina Petrache

    1. Division of Pulmonary, Allergy, Critical, Department of Medicine, Indiana University School of Medicine, Indianapolis, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Focuses on the (patho-) physiological role and function of sphingolipids
  • Provides insight into the molecular biology of common human diseases
  • Represents together with Volume 215 a unique comprehensive collection of important aspects of sphingolipid basic biology, functioning and applied research ?
  • Includes supplementary material: sn.pub/extras

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 216)

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Table of contents (23 chapters)

  1. Front Matter

    Pages i-viii
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  2. Sphingolipids in Cancer

    1. Front Matter

      Pages 1-1
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    2. Sphingosine Kinase/Sphingosine 1-Phosphate Signaling in Cancer Therapeutics and Drug Resistance

      • Shanmugam Panneer Selvam, Besim Ogretmen
      Pages 3-27

    3. Using ASMase Knockout Mice to Model Human Diseases

      • Guoqiang Hua, Richard Kolesnick
      Pages 29-54

    4. New Perspectives on the Role of Sphingosine 1-Phosphate in Cancer

      • Susan Pyne, Nigel J. Pyne
      Pages 55-71

    5. Sphingolipids and Response to Chemotherapy

      • Marie-Thérèse Dimanche-Boitrel, Amélie Rebillard
      Pages 73-91

    6. Lung Cancer and Lung Injury: The Dual Role of Ceramide

      • Tzipora Goldkorn, Samuel Chung, Simone Filosto
      Pages 93-113

    7. Sphingolipids’ Role in Radiotherapy for Prostate Cancer

      • Carla Hajj, Adriana Haimovitz-Friedman
      Pages 115-130

  3. Sphingolipids in Cardio-Reno-vascular Diseases

    1. Front Matter

      Pages 131-131
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    2. Sphingolipid Metabolism and Atherosclerosis

      • Xian-Cheng Jiang, Jing Liu
      Pages 133-146

    3. Cardiovascular Effects of Sphingosine-1-Phosphate (S1P)

      • Bodo Levkau
      Pages 147-170

    4. Cross Talk Between Ceramide and Redox Signaling: Implications for Endothelial Dysfunction and Renal Disease

      • Pin-Lan Li, Yang Zhang
      Pages 171-197

  4. Sphingolipids in Inflammation, Infection and Lung Diseases

    1. Front Matter

      Pages 199-199
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    2. Sphingolipids in Lung Endothelial Biology and Regulation of Vascular Integrity

      • Taimur Abbasi, Joe G. N. Garcia
      Pages 201-226

    3. Sphingolipids in Acute Lung Injury

      • Stefan Uhlig, Yang Yang
      Pages 227-246

    4. The Involvement of Sphingolipids in Chronic Obstructive Pulmonary Diseases

      • Irina Petrache, Daniela N. Petrusca
      Pages 247-264

    5. Ceramide in Cystic Fibrosis

      • Heike Grassmé, Joachim Riethmüller, Erich Gulbins
      Pages 265-274

    6. Regulation of the Sphingosine Kinase/Sphingosine 1-Phosphate Pathway

      • K. Alexa Orr Gandy, Lina M. Obeid
      Pages 275-303

    7. Bacterial Infections and Ceramide

      • Heike Grassmé, Katrin Anne Becker
      Pages 305-320

    8. Viral Infections and Sphingolipids

      • Jürgen Schneider-Schaulies, Sibylle Schneider-Schaulies
      Pages 321-340
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Keywords

About this book

Sphingolipids are lipid components of the plasma membrane of eukaryotic cells with an important function in signaling mechanisms in the cell. This  book provides insight into the physiological and pathophysiological role of sphingolipids and in particular its derivative ceramide. The function of Sphingolipids in cell signaling with regard to infectious and lung diseases, cancer, cardiovascular diseases and neuropsychiatric disorders are described and treated in distinct parts. Together with Volume 215 from the same Editors, the collection represents a unique, comprehensive work on Sphingolipids, providing information on both: Sphingolipid basic biology  as well as its important function in a (patho)physiological context. The book is written for scientists in pharmacology, biochemistry and cell biology with a focus on biomedical research as well as for clinicians in pharmacology, oncology, cardiology, neurology and infectious disease.   ​

Editors and Affiliations

  • , Department of Molecular Biology, University of Duisburg-Essen, Essen, Germany

    Erich Gulbins

  • Division of Pulmonary, Allergy, Critical, Department of Medicine, Indiana University School of Medicine, Indianapolis, USA

    Irina Petrache

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