Glioma Cell Biology

Editors: Sedo, Aleksi, Mentlein, Rolf (Eds.)

  • Covers genetic, epigenetic, cell- and molecular biology of glioma cells
  • Depicts the cell-cell interaction of glioma cells with their environment
  • Presents experimental research models for glioma research
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  • ISBN 978-3-7091-1431-5
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Hardcover $209.00
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  • ISBN 978-3-7091-1430-8
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Softcover $209.00
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  • ISBN 978-3-7091-4841-9
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About this book

Gliomas are fatal diseases, but also represent good models for tumor research with the aim to eventually discover new and appropriate therapeutics against this disease. Glioma experimental research models are of help to investigate tumorigenesis (tumor stem cell theory versus "classical" opinions), tumor angiogenesis (since they are highly vascularized) and tumor invasion (since they grow without limits). In addition, they have a very special microenvironment (the brain) and limited tumor stroma cells (mainly microglia and endothelial cells). This book addresses the molecular mechanisms of the various tumor stages, describes the interaction with the tumor microenvironment and furthermore depicts experimental models for Glioma research and future therapeutic concepts. The book is composed and written for Scientists and Medical Doctors in Oncology, Neurosciences and Molecular Biology. ​

About the authors

Aleksi Sedo started his career as a Research Associate at the Institute of Chest Diseases in Prague, Czech Republic in 1987. He subsequently served as a Visiting Scientist and Professor at the Institute of Mutagenesis and Differentiation, which is funded by the Consiglio Nazionale de la Recherche (CNR) in Pisa, Italy. In 1996 he became an Assistant Professor of Biochemistry at the Institute of Medical Chemistry and Biochemistry, 1st Faculty of Medicine, Charles University, Prague and was appointed Associate Professor in 1997. From 1999 to 2002 Professor Sedo was a Senior Scientist at Procter and Gamble in Germany. Today he is a Professor of Medical Chemistry and Biochemistry, Head of the Institute of Biochemistry and Experimental Oncology, and Dean of the 1st Faculty of Medicine, Charles University in Prague. His research is oriented on the role of proteases in the cancer development, mostly in gliomagenesis.

Rolf Mentlein studied chemistry and biology, undertook his PhD thesis in natural chemistry (1976) and subsequently performed his postdoctoral qualification (“Habilitation”) in biochemistry at the Christian-Albrechts-University in Kiel, Germany. After post doc times and positions in Bergen (Haukeland Hospital, Norway), Osnabrück (University, Germany) and Cambridge (Babraham Institute, UK), he was appointed 1988 as a Professor for Biochemistry and Cell Biology at the University of Kiel. His main research subjects included lipases, proteases and bioactive peptides (peptide hormones, neuropeptides, growth factors and chemokines), in particular their regulation, receptors, signal transduction and functions in the brain and tumors. Among others, his research resulted in the development of new types of anti-diabetic drugs. He published about 200 original research and review articles, edited a book on neuropeptides, and is editor and reviewer for several scientific journals. 

Table of contents (14 chapters)

  • Cancer Stem Cells and Glioblastoma

    Hamerlik, Petra

    Pages 3-22

  • Epigenetic Changes in Gliomas

    Puduvalli, Vinay K.

    Pages 23-45

  • Signaling Cascades Driving the Malignant Phenotype of Glioma Cells

    Nakada, Mitsutoshi (et al.)

    Pages 47-75

  • MicroRNAs in the Molecular Pathology of Gliomas

    Sana, Jiri (et al.)

    Pages 77-116

  • Autophagy in Glioma Cells

    Ciechomska, Iwona Anna (et al.)

    Pages 117-149

Buy this book

eBook $159.00
price for USA (gross)
  • ISBN 978-3-7091-1431-5
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $209.00
price for USA
  • ISBN 978-3-7091-1430-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $209.00
price for USA
  • ISBN 978-3-7091-4841-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Glioma Cell Biology
Editors
  • Aleksi Sedo
  • Rolf Mentlein
Copyright
2014
Publisher
Springer-Verlag Wien
Copyright Holder
Springer-Verlag Wien
eBook ISBN
978-3-7091-1431-5
DOI
10.1007/978-3-7091-1431-5
Hardcover ISBN
978-3-7091-1430-8
Softcover ISBN
978-3-7091-4841-9
Edition Number
1
Number of Pages
X, 468
Number of Illustrations and Tables
4 b/w illustrations, 52 illustrations in colour
Topics