Homocysteine in Protein Structure/Function and Human Disease

Chemical Biology of Homocysteine-containing Proteins

Authors: Jakubowski, Hieronim

  • Gives new aspects in protein chemistry - protein structure/function modifications by homocysteine
  • Presents relationship between homocysteinylated proteins, human disease and life span
  • Covers description of procedures of detection, quantification and study of proteins by homocysteine
  • Discusses utility of homocysteine-containing proteins as diagnostic markers​
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eBook $149.00
price for USA (gross)
  • ISBN 978-3-7091-1410-0
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $189.00
price for USA
  • ISBN 978-3-7091-1409-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $189.00
price for USA
  • ISBN 978-3-7091-1720-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Excess of homocysteine, a product of the metabolism of the essential amino acid methionine, is associated with poor health, is linked to heart and brain diseases in general human populations, and accelerates mortality in heart disease patients. Neurological and cardiovascular abnormalities occur in patients with severe genetic hyperhomocysteinemia and lead to premature death due to vascular complications. Although it is considered a non-protein amino acid, studies over the past dozen years have discovered mechanisms by which homocysteine becomes a component of proteins. Homocysteine-containing proteins lose their normal biological function and become auto-immunogenic and pro-thrombotic. In this book, the author, a pioneer and a leading contributor to the field, describes up-to date studies of the biological chemistry of homocysteine-containing proteins, as well as pathological consequences and clinical implications of their formation. This is a comprehensive account of the broad range of basic science and medical implications of homocysteine-containing proteins for health and disease. ​

Table of contents (7 chapters)

  • Introduction

    Jakubowski, Hieronim

    Pages 1-5

  • An Overview of Homocysteine Metabolism

    Jakubowski, Hieronim

    Pages 7-18

  • Homocysteine-Thiolactone

    Jakubowski, Hieronim

    Pages 19-53

  • Discoveries of Protein S- and N-Homocysteinylation

    Jakubowski, Hieronim

    Pages 55-57

  • N-Homocysteinyl-Proteins

    Jakubowski, Hieronim

    Pages 59-105

Buy this book

eBook $149.00
price for USA (gross)
  • ISBN 978-3-7091-1410-0
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $189.00
price for USA
  • ISBN 978-3-7091-1409-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $189.00
price for USA
  • ISBN 978-3-7091-1720-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Homocysteine in Protein Structure/Function and Human Disease
Book Subtitle
Chemical Biology of Homocysteine-containing Proteins
Authors
Copyright
2013
Publisher
Springer-Verlag Wien
Copyright Holder
Springer-Verlag Wien
eBook ISBN
978-3-7091-1410-0
DOI
10.1007/978-3-7091-1410-0
Hardcover ISBN
978-3-7091-1409-4
Softcover ISBN
978-3-7091-1720-0
Edition Number
1
Number of Pages
XIII, 166
Topics