Kinetics of Enzyme-Modifier Interactions

Selected Topics in the Theory and Diagnosis of Inhibition and Activation Mechanisms

Authors: Baici, Antonio

  • Covers all known mechanisms of enzyme inhibition and activation
  • Only modern and robust methods are discussed
  • Includes step-by-step guided practical examples to accompany theoretical explanations
  • Shows diagnostic keys to enzyme-modifier interaction mechanisms that have never been published before
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eBook $139.00
price for USA (gross)
  • ISBN 978-3-7091-1402-5
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $179.00
price for USA
  • ISBN 978-3-7091-1401-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $179.00
price for USA
  • Customers within the U.S. and Canada please contact Customer Service at 1-800-777-4643, Latin America please contact us at +1-212-460-1500 (Weekdays 8:30am – 5:30pm ET) to place your order.
  • Due: December 15, 2016
  • ISBN 978-3-7091-1949-5
  • Free shipping for individuals worldwide
About this book

The kinetic mechanisms by which enzymes interact with inhibitors and activators, collectively called modifiers, are scrutinized and ranked taxonomically into autonomous species in a way similar to that used in the biological classification of plants and animals. The systematization of the mechanisms is based on two fundamental characters: the allosteric linkage between substrate and modifier and the factor by which a modifier affects the catalytic constant of the enzyme. Combinations of the physically significant states of these two characters in an ancestor-descendant-like fashion reveal the existence of seventeen modes of interaction that cover the needs of total, partial and fine-tuning modulation of enzyme activity. These interactions comprise five linear and five hyperbolic inhibition mechanisms, five nonessential activation mechanisms and two hybrid species that manifest either hyperbolic inhibition or nonessential activation characteristics depending on substrate concentration. Five essential activation mechanisms, which are taxonomically independent of the mentioned basic species, complete the inventory of enzyme modifiers. Often masked under conventional umbrella terms or treated as anomalous cases, all seventeen basic inhibition and nonessential activation mechanisms are represented in the biochemical and pharmacological literature of this and the past century, either in the form of rapid or slow-onset reversible interactions, or as irreversible modification processes.

The full potential of enzyme inhibitors and activators can only be appreciated after elucidating the details of their kinetic mechanisms of action exploring the entire range of physiologically significant reactant concentrations. This book highlights the wide spectrum of allosteric enzyme modification in physiological occurrences as well as in pharmacological and biotechnological applications that embrace simple and multiple enzyme-modifier interactions. The reader is guided in the journey through this still partly uncharted territory with the aid of mechanistically-oriented criteria aimed at showing the logical way towards the identification of a particular mechanism.

Table of contents (10 chapters)

  • Basic Knowledge

    Baici, Antonio

    Pages 1-64

  • The General Modifier Mechanism

    Baici, Antonio

    Pages 65-125

  • Taxonomy of Enzyme–Modifier Interactions and the Specific Velocity Plot

    Baici, Antonio

    Pages 127-169

  • Complements to Enzyme–Modifier Interactions

    Baici, Antonio

    Pages 171-207

  • The Basic Mechanisms of Inhibition and Nonessential Activation

    Baici, Antonio

    Pages 209-293

Buy this book

eBook $139.00
price for USA (gross)
  • ISBN 978-3-7091-1402-5
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $179.00
price for USA
  • ISBN 978-3-7091-1401-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $179.00
price for USA
  • Customers within the U.S. and Canada please contact Customer Service at 1-800-777-4643, Latin America please contact us at +1-212-460-1500 (Weekdays 8:30am – 5:30pm ET) to place your order.
  • Due: December 15, 2016
  • ISBN 978-3-7091-1949-5
  • Free shipping for individuals worldwide
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Bibliographic Information

Bibliographic Information
Book Title
Kinetics of Enzyme-Modifier Interactions
Book Subtitle
Selected Topics in the Theory and Diagnosis of Inhibition and Activation Mechanisms
Authors
Copyright
2015
Publisher
Springer-Verlag Wien
Copyright Holder
Springer-Verlag Wien
Distribution Rights
Distribution rights for India: Delhi Book Store, New Delhi, India
eBook ISBN
978-3-7091-1402-5
DOI
10.1007/978-3-7091-1402-5
Hardcover ISBN
978-3-7091-1401-8
Softcover ISBN
978-3-7091-1949-5
Edition Number
1
Number of Pages
XVII, 489
Number of Illustrations and Tables
221 b/w illustrations
Topics