Computational Medicine

Tools and Challenges

Editors: Trajanoski, Zlatko (Ed.)

  • Shows the connection from basic bioinformatics to application in biological as well as therapeutic questions
  • Gives insight into state-of-the-art IT solutions for application in medicine
  • Written by a experts in the respective fields
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About this book

Computational methodologies and modeling play a growing role for investigating mechanisms, and for the diagnosis and therapy of human diseases. This progress gave rise to computational medicine, an interdisciplinary field at the interface of computer science and medicine. The main focus of computational medicine lies in the development of data analysis methods and mathematical modeling as well as computational simulation techniques specifically addressing medical problems. In this book, we present a number of computational medicine topics at several scales: from molecules to cells, organs, and organisms. At the molecular level, tools for the analysis of genome variations as well as cloud computing resources for medical genetics are reviewed. Then, an analysis of gene expression data and the application to the characterization of microbial communities are highlighted. At the protein level, two types of analyses for mass spectrometry data are reviewed: labeled quantitative proteomics and lipidomics, followed by protein sequence analysis and a 3D structure and drug design chapter. Finally, three chapters on clinical applications focus on the integration of biomolecular and clinical data for cancer research, biomarker discovery, and network-based methods for computational diagnostics.

About the authors

W. Wolfgang Fleischhacker ist Facharzt für Psychiatrie und medizinische Psychotherapie. Er hat in Innsbruck studiert und wurde nach einem Forschungsaufenthalt in den USA 1983 als Professor an die Abteilung für Biologische Psychiatrie in Innsbruck berufen, seit 2008 ist er Geschäftsführender Direktor des Departments für Psychiatrie und Psychotherapie an der Medizinischen Universität Innsbruck.

Hartmann Hinterhuber ist emeritierter Professor für Psychiatrie an der Medizinischen Universität Innsbruck. Nach seinem Studium in Innsbruck und Padua absolvierte er seine Facharztausbildung in Bologna (Italien). Von 1983 bis 2008 war er Direktor der Univ.-Klinik für Psychiatrie Innsbruck. Derzeit ist er Leiter einer großen sozialpsychiatrischen Institution.

Hartmann Hinterhuber ist emeritierter Professor für Psychiatrie an der Medizinischen Universität Innsbruck. Nach seinem Studium in Innsbruck und Padua absolvierte er seine Facharztausbildung in Bologna (Italien). Von 1983 bis 2008 war er Direktor der Univ.-Klinik für Psychiatrie Innsbruck. Derzeit ist er Leiter einer großen sozialpsychiatrischen Institution.

Table of contents (11 chapters)

  • Bioinformatic Tools for the Search of Disease-Associated Variations

    Coassin, Stefan (et al.)

    Pages 1-25

  • Cloud Computing

    Forer, Lukas (et al.)

    Pages 27-36

  • High-Throughput Characterization and Comparison of Microbial Communities

    Halwachs, Bettina (et al.)

    Pages 37-57

  • Microarray Meta-Analysis: From Data to Expression to Biological Relationships

    Feichtinger, Julia (et al.)

    Pages 59-77

  • Analysis of Labeled Quantitative Mass Spectrometry Proteomics Data

    Breitwieser, Florian Paul (et al.)

    Pages 79-91

Buy this book

eBook $189.00
price for USA (gross)
  • ISBN 978-3-7091-0947-2
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $239.00
price for USA
  • ISBN 978-3-7091-0946-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Computational Medicine
Book Subtitle
Tools and Challenges
Editors
  • Zlatko Trajanoski
Copyright
2012
Publisher
Springer-Verlag Wien
Copyright Holder
Springer-Verlag Wien
eBook ISBN
978-3-7091-0947-2
DOI
10.1007/978-3-7091-0947-2
Hardcover ISBN
978-3-7091-0946-5
Edition Number
1
Number of Pages
IX, 203
Topics