Jak-Stat Signaling : From Basics to Disease

Editors: Decker, Thomas, Müller, Mathias (Eds.)

  • First comprehensive book about Jak-Stat signaling in 7 years
  • Gives overview and fascinating insight into the newest research findings on Jak-Stat signaling in cancer research and cell metabolism 
  • Very well structured Deals with basic as well as with clinical aspects of Jak-Stat signaling
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Buy this book

eBook $159.00
price for USA (gross)
  • ISBN 978-3-7091-0891-8
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $209.00
price for USA
  • ISBN 978-3-7091-0890-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $209.00
price for USA
  • ISBN 978-3-7091-1752-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

JAK tyrosine kinases and STAT transcription factors constitute a signaling pathway, which is activated by cytokines. By activating gene transcription it regulates essential biological responses to environmental cues. The Jak-Stat pathway is involved in the regulation of cell development, differentiation, proliferation and apoptosis. Improper function may contribute to hematopoietic malignancies and cancer. This book provides comprehensive insights into the latest basic and clinical developments in the field. The first part reviews recent findings and new technologies pertaining to basics of Jak-Stat function. The second part describes the evolution of Jak-Stat signaling and the role of the pathway in invertebrate organisms. The third part focuses on Jak-Stat signaling in hematopoietic cells under both physiological and pathophysiological conditions. Finally, chapters in the fourth section describe the relationship of Jak-Stat signaling to various states of disease, particularly infection, leukemias and solid cancers. The book is intended for all scientists in molecular biology, biochemistry and cell biology dealing with biomedical issues.

About the authors

Thomas Decker obtained a masters degree in Biology and, in 1986, his PhD at the Albert-Ludwig University of Freiburg, Both his PhD project and his subsequent postdoctoral research at the Rockefeller University, New York, USA, concerned the immunological activity and molecular biology of interferons. This line of research led to intensive investigation of Jak-Stat signal transduction which continued duing subsequent group leader positions and professorships at the Fraunhofer Society, Hannover, Germany, the Karolinska Institute, Stockholm, Sweden and, finally, the University of Vienna where he currently holds the position of a full professor of immunobiology. Work in Decker’s laboratory revolves around interferons, the Jak-Stat signalling pathway and mechanisms of gene activation in bacterial infections.

Mathias Müller studied veterinary medicine at the Ludwig-Maximilians University Munich (Germany) and completed his PhD thesis at the Gene Center Munich. During a postdoctoral fellowship at the ICRF (Imperial Cancer Research Fund, London UK; now CRUK, Cancer Research UK) he entered the field of interferon signal transduction and participated in the pioneering studies that led to the identification of the biological roles of Jaks and Stats by genetic complementation of cytokine signalling defective mutant cell lines. In 1998 he was appointed Full Professor of Veterinary Biotechnology and Molecular Genetics at the University of Veterinary Medicine Vienna. His laboratory focuses on the use of transgenic models for studying JAK–STAT signalling networks.

Reviews

From the reviews:

“This well-illustrated book provides a comprehensive look at the latest basic and clinical developments on the involvement of Jak-Stat pathway in the regulation of cell development, differentiation, proliferation and apoptosis, the malfunctioning of which results in hematopoietic malignancies and cancer. … The book is well-illustrated with a number of beautiful color figures. … Molecular biologists, biochemists, cell biologists, and clinical oncologists will find this book useful.” (Omer Iqbal, Doody’s Review Service, November, 2012)

Table of contents (22 chapters)

  • The Continuing Fascination with Jaks and Stats: An Introduction

    Decker, Thomas (et al.)

    Pages 1-4

  • Regulation of JAKs: Insights Gleaned from the Functional Protein Domains

    Haan, Claude (et al.)

    Pages 5-25

  • Nuclear Functions of the Janus Kinases

    Dawson, Mark A. (et al.)

    Pages 27-46

  • Self-association of STAT Proteins from Monomers to Paracrystals

    Droescher, Mathias (et al.)

    Pages 47-63

  • How Stats Interact with the Molecular Machinery of Transcriptional Activation

    Jamieson, Amanda M. (et al.)

    Pages 65-89

Buy this book

eBook $159.00
price for USA (gross)
  • ISBN 978-3-7091-0891-8
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $209.00
price for USA
  • ISBN 978-3-7091-0890-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $209.00
price for USA
  • ISBN 978-3-7091-1752-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Jak-Stat Signaling : From Basics to Disease
Editors
  • Thomas Decker
  • Mathias Müller
Copyright
2012
Publisher
Springer-Verlag Wien
Copyright Holder
Springer-Verlag Wien
eBook ISBN
978-3-7091-0891-8
DOI
10.1007/978-3-7091-0891-8
Hardcover ISBN
978-3-7091-0890-1
Softcover ISBN
978-3-7091-1752-1
Edition Number
1
Number of Pages
XIV, 450
Topics