Proteases: Structure and Function

Editors: Brix, Klaudia, Stöcker, Walter (Eds.)

  • Written by designated experts in the field defined models are described
  • Ensures a better understanding of biological significance of proteinases
  • Clearly shows the diversity and networking of enzymes
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eBook $189.00
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  • ISBN 978-3-7091-0885-7
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Hardcover $239.00
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  • ISBN 978-3-7091-0884-0
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Softcover $239.00
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  • ISBN 978-3-7091-1939-6
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About this book

Proteolysis is an irreversible posttranslational modification affecting each and every protein from its biosynthesis to its degradation. Limited proteolysis regulates targeting and activity throughout the lifetime of proteins. Balancing proteolysis is therefore crucial for physiological homeostasis. Control mechanisms include proteolytic maturation of zymogens resulting in active proteases and the shut down of proteolysis by counteracting endogenous protease inhibitors. Beyond the protein level, proteolytic enzymes are involved in key decisions during development that determine life and death – from single cells to adult individuals. In particular, we are becoming aware of the subtle role that proteases play in signaling events within proteolysis networks, in which the enzymes act synergistically and form alliances in a web-like fashion. Proteases come in different flavors. At least five families of mechanistically distinct enzymes and even more inhibitor families are known to date, many family members are still to be studied in detail. We have learned a lot about the diversity of the about 600 proteases in the human genome and begin to understand their physiological roles in the degradome. However, there are still many open questions regarding their actions in pathophysiology. It is in this area where the development of small molecule inhibitors as therapeutic agents is extremely promising. Approaching proteolysis as the most important, irreversible post-translational protein modification essentially requires an integrated effort of complementary research disciplines. In fact, proteolytic enzymes seem as diverse as the scientists working with these intriguing proteins. This book reflects the efforts of many in this exciting field of research where team and network formations are essential to move ahead.

Table of contents (15 chapters)

  • Protease Families, Evolution and Mechanism of Action

    Rawlings, Neil D.

    Pages 1-36

  • Kinetics of the Interaction of Peptidases with Substrates and Modifiers

    Baici, Antonio (et al.)

    Pages 37-84

  • Compartmentalization of Proteolysis

    Brix, Klaudia (et al.)

    Pages 85-125

  • Cathepsins: Getting in Shape for Lysosomal Proteolysis

    Erickson, Ann H. (et al.)

    Pages 127-173

  • Limited and Degradative Proteolysis in the Context of Posttranslational Regulatory Networks: Current Technical and Conceptional Advances

    Tholen, Stefan (et al.)

    Pages 175-216

Buy this book

eBook $189.00
price for USA (gross)
  • ISBN 978-3-7091-0885-7
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $239.00
price for USA
  • ISBN 978-3-7091-0884-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $239.00
price for USA
  • ISBN 978-3-7091-1939-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Proteases: Structure and Function
Editors
  • Klaudia Brix
  • Walter Stöcker
Copyright
2013
Publisher
Springer-Verlag Wien
Copyright Holder
Springer-Verlag Wien
eBook ISBN
978-3-7091-0885-7
DOI
10.1007/978-3-7091-0885-7
Hardcover ISBN
978-3-7091-0884-0
Softcover ISBN
978-3-7091-1939-6
Edition Number
1
Number of Pages
XII, 564
Number of Illustrations and Tables
33 b/w illustrations, 65 illustrations in colour
Topics