Bio-orthopaedics

1. Front Matter

   Pages i-xix

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2. Overview

   1. Front Matter

      Pages 1-1

      PDF

   2. The Optimization of Natural Healing

      • Christopher Rogers, Alberto Gobbi

      Pages 3-24

   3. Overview of Orthobiology and Biomechanics

      • Jorge Chahla, Mark Cinque, Robert F. LaPrade, Bert Mandelbaum

      Pages 25-40

   4. Education and Understanding Orthobiologics: Then and Now

      • Steven Sampson, Hunter Vincent, Mary Ambach

      Pages 41-46

   5. Orthobiologics: Regulation in Different Parts of the World

      • Jason A. Grieshober, Eyitayo Fakunle, Ralph A. Gambardella

      Pages 47-63

   6. Tissue Engineering and New Biomaterials

      • Mustafa Karahan, Rustu Nuran

      Pages 65-70

   7. Physiology and Homeostasis of Musculoskeletal Structures, Injury Response, Healing Process, and Regenerative Medicine Approaches

      • Kaitlyn E. Whitney, Ioanna Bolia, Jorge Chahla, Hajime Utsunomiya, Thos A. Evans, Matthew Provencher et al.

      Pages 71-85

   8. Host Environment: Scaffolds and Signaling (Tissue Engineering) Articular Cartilage Regeneration: Cells, Scaffolds, and Growth Factors

      • Livia Roseti, Brunella Grigolo

      Pages 87-103

   9. Current State for Clinical Use of Stem Cells and Platelet-Rich Plasma

      • Volker Musahl, Conor I. Murphy, Thomas P. Pfeiffer, Jeremy M. Burnham, Gregory V. Gasbarro

      Pages 105-124

   10. Xenografts: Biologic Combination Devices

       • Kevin R. Stone

       Pages 125-133

   11. Orthopedic Sports Disorders: Genetic and Molecular Aspects

       • Moises Cohen, Diego Costa Astur, João Victor Novaretti

       Pages 135-138

   12. Cell-Free Scaffolds for the Treatment of Chondral and Osteochondral Lesions

       • F. Perdisa, A. Sessa, G. Filardo, M. Marcacci, E. Kon

       Pages 139-149

   13. Understanding Scaffolds, Stem Cells, and Growth Factors

       • R. Cugat, P. Alvarez-Diaz, D. Barastegui, M. Garcia-Balletbo, P. Laiz, R. Seijas et al.

       Pages 151-159

   14. Cell Culture Approaches for Articular Cartilage: Repair and Regeneration

       • Eyitayo S. Fakunle, John G. Lane

       Pages 161-172

   15. Gene Therapy

       • Henning Madry, Patrick Orth, Jagadeesh K. Venkatesan, Ke Tao, Lars Goebel, Magali Cucchiarini

       Pages 173-183

   16. The Use of a Large Animal Model and Robotic Technology to Validate New Biotherapies for ACL Healing

       • Jonquil R. Mau, Huizhi Wang, Savio L-Y. Woo

       Pages 185-196

   17. Use of Stem Cells in Orthopaedics

       • Konrad Slynarski, Hieronymus P. Stevens, Joris A. van Dongen, Filip Baszczeski, Lukasz Lipinski

       Pages 197-204

   18. Stem Cells in Joint Repair

       • Celeste Scotti, Kota Koizumi, Norimasa Nakamura

       Pages 205-211

3. Muscle

   1. Front Matter

      Pages 213-213

      PDF

This book introduces the exciting field of orthobiology, which will usher in a new array of therapeutic approaches that stimulate the body’s natural resources to regenerate musculoskeletal tissues damaged by trauma or disease. The book addresses a range of key topics and discusses emerging approaches that promise to offer effective alternatives to traditional treatments for injuries to bone, cartilage, muscles, ligaments, and tendons. It explains in detail how a variety of innovative products, including biomaterials, growth factors, and autogenous cells, together provide the basis for the regeneration of these musculoskeletal structures and how recent scientific progress has created unique opportunities to address pathological situations that until recently have been treated with unsatisfactory results. The authors are experts from across the world who come together to provide a truly global overview. The book is published in collaboration with ISAKOS. It will be invaluable for all with an interest in this area of medicine, which has already attained huge popularity in Orthopaedics and Sports Medicine and has also attracted the attention of the lay public.

• Stem cells
• Scaffold
• Platelet Rich Plasma
• Tissue engineering
• Growth factors

• O.A.S.I. Bioresearch Foundation NPO, Milan, Italy

  Alberto Gobbi

• Clínica do Dragão, Espregueira-Mendes Sports Centre – FIFA Medical Centre of Excellence, Porto, Portugal

  João Espregueira-Mendes

• Musculoskeletal and Joint Research Foundation, San Diego, USA

  John G. Lane

• Department of Orthopedics, Acibadem University, Istanbul, Turkey

  Mustafa Karahan

Alberto Gobbi, MD is a board-certified surgeon and specialist in Orthopedics and Traumatology and Sports Medicine. In his youth he played sport at a national level. He performs scientific, surgical and educational activities at a national and international level. He currently serves as the Vice president of ICRS (International Cartilage Repair Society) and Chair of their Education Committee. He holds various other positions within some of the most prestigious medical societies in the field of orthopedics, arthroscopy, sports medicine and scientific research. He is also a Visiting Professor at University College San Diego where he lectures several times a year. He has published hundreds of peer review articles and has been Editor on books and book chapters for various publishing houses. Dr. Gobbi’s office is located in Milan, he is also Founder and President of O.A.S.I. Bioresearch Foundation Gobbi Onlus, a Non-Profit Organisation, accredited by the Italian Ministry of Health and recognized as an International Teaching Center by ISAKOS (International Society of Arthroscopy, Knee Surgery & Orthopaedic Sports Medicine) and ICRS (International Cartilage Repair Society). The O.A.S.I. Foundation promotes research into cartilage, joint aging and sports lesions through a network of collaborators from all over the world.




Joao Espregueira-Mendes, MD, PhD, has been Professor of Orthopaedic Traumatology and Chairman of the Orthopaedic Department at Minho University, Portugal, since 2005. In addition, he is Director of Clínica do Dragão - Espregueira-Mendes Sports Centre - FIFA Medical Centre of Excellence, FC Porto Dragão Stadium, Porto, Portugal. His further posts include Orthopaedic Surgeon of FC Porto and Senior Researcher in Biomaterials, Biodegradables, and Biomimetics in the Department of Polymer Engineering at Minho University. Dr. Espregueira-Mendes was President of the European Society of Knee Surgery, Sports Trauma and Arthroscopy (ESSKA) from 2012 to 2014 and he is Treasurer and Chairman of the Publication Committee of ISAKOS. He is a member of the editorial board of Knee Surgery, Sports Traumatology, Arthroscopy. 

John G. Lane, MD, is a clinician in San Diego who has a voluntary Clinical Associate Professor appointment at the University of California, San Diego in the Department of Orthopedic Surgery.  Dr. Lane is a member of AAOS, AANA, AOSSM, ISAKOS, and ICRS.  Currently he is a member of the membership committee of ICRS and the education committee of ISAKOS. His clinical field of practice focuses on complex knee and shoulder injuries. He has collaborated with Professor Amiel at UCSD since 1989, working in the fields of ligament and cartilage. He has received grants for a variety of research projects and is currently collaborating with Dr. Alberto Gobbi of Milan in evaluating the effects of adipose-derived stem cells in the treatment of articular cartilage lesions. He has published 26 peer-reviewed manuscripts and one book chapter.

Mustafa Karahan, MD, is Adjunct Professor of Orthopaedics at the Department of Orthopaedics, Acibadem University, Istanbul, Turkey, where he is actively involved in CASE (Center for Advance Simulation and Training), which hosts European Basic Arthroscopy Courses. Dr. Karahan is an internationally active orthopedic surgeon who works mainly on sports traumatology, knee surgery, shoulder surgery, and arthroscopy. He founded the Marmara University Sports Sciences and Health Research Center in Istanbul in 2004. Dr. Karahan is an Executive Board Member of ESSKA and Editor of ESSKA Academy, the online teaching portal of ESSKA. He is also the vice Chair of the Publication Committee of ISAKOS. He has published more than 70 scientific articles in peer-reviewed journals and is an editorial board member of the American Journal of Sports Medicine (AJSM), Arthroscopy, KSSTA, and Journal of ISAKOS.

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