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Multiple Origins of Sex Differences in Brain

Neuroendocrine Functions and their Pathologies

  • Book
  • © 2013

Overview

Editors:
  1. Donald W. Pfaff

    1. , Lab. of Biochem. and Molec. Biology, The Rockefeller University, New York, USA

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  2. Yves Christen

    1. Fondation Ipsen, Boulogne Billancourt, France

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    You can also search for this editor in PubMed   Google Scholar

  • Latest research on epigenetics and brain development
  • Presents animal and human studies
  • Written by leading international experts in the field
  • Includes supplementary material: sn.pub/extras

Part of the book series: Research and Perspectives in Endocrine Interactions (RPEI)

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Table of contents (11 chapters)

  1. Front Matter

    Pages i-xiii
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  2. Hormone-Dependent Chromatin Modifications Related to Sexually Differentiated Behaviors

    • Khatuna Gagnidze, Donald W. Pfaff
    Pages 1-19

  3. Importance of Genomic Imprinting in the Evolution and Development of the Maternal Brain

    • Barry E. Keverne
    Pages 21-33

  4. Genomic Imprinting in the Adult and Developing Brain

    • Catherine Dulac, Gregg Christopher
    Pages 35-41

  5. The Synapse: Differences Between Men and Women

    • Javier DeFelipe, Lidia Alonso-Nanclares
    Pages 43-57

  6. Gonadal Hormone Influences on Human Neurobehavioral Development: Outcomes and Mechanisms

    • Melissa Hines
    Pages 59-69

  7. Congenital Adrenal Hyperplasia: Neuroendocrine, Behavioral and Cognitive Implications

    • Phyllis W. Speiser
    Pages 71-79

  8. Genetic Variation Within Serotonin Genes, Hormones, and Aggression

    • Francesca Ducci, Laura Bevilacqua, Paola Landi, David Goldman
    Pages 81-102

  9. Multiple Origins of Sex Differences in Attention Deficit Hyperactivity Disorder

    • James M. Swanson, Kimberly D. Lakes, Tim L. Wigal, Nora D. Volkow
    Pages 103-122

  10. Fetal Testosterone in Mind: Implications for Autism

    • Bonnie Auyeung, Simon Baron-Cohen
    Pages 123-137

  11. Sex Differences in HPA and HPG Axes Dysregulation in Major Depressive Disorder: The Role of Shared Brain Circuitry Between Hormones and Mood

    • Jill M. Goldstein, Laura M. Holsen, Robert Handa, Stuart Tobet
    Pages 139-163

  12. Estrogens: Protective or Risk Factors in the Injured Brain?

    • Phyllis M. Wise, Candice M. Brown, Jodi L. Downs
    Pages 165-178

  13. Back Matter

    Pages 179-181
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Keywords

About this book

In theoretical terms, sex differences in brains and behaviors of laboratory animals offer the possibility of fascinating scientific studies on a range of molecular phenomena such as genomic imprinting, DNA methylation, chromatin protein modification, non-coding DNA, potentially resulting in important neuroanatomical and neurochemical sex differences in the brain. Such sex differences could arise consequent to exposures to testosterone early in development, or to other effects deriving from the Y chromosome. However, this general subject has been treated with much hyperbole. Historically, sex differences were assumed to be present where they did not really exist, e.g. with respect to mathematics, executive leadership, etc. etc. Under what circumstances do we really care about sex differences in brain and behavior? These circumstances concern human maladies whose diagnoses are much different between boys and girls, or between women and men. Prominent examples discussed in this volume include autism, attention deficit hyperactivity disorders and congenital adrenal hyperplasia. In fact, infant boys are more susceptible than infant girls to a variety of disorders that arise early in development. This volume then ends with a consideration of effects of estrogenic hormones on the injured brain, and their roles as protective agents.

Editors and Affiliations

  • , Lab. of Biochem. and Molec. Biology, The Rockefeller University, New York, USA

    Donald W. Pfaff

  • Fondation Ipsen, Boulogne Billancourt, France

    Yves Christen

Bibliographic Information

  • Book Title: Multiple Origins of Sex Differences in Brain

  • Book Subtitle: Neuroendocrine Functions and their Pathologies

  • Editors: Donald W. Pfaff, Yves Christen

  • Series Title: Research and Perspectives in Endocrine Interactions

  • DOI: https://doi.org/10.1007/978-3-642-33721-5

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2013

  • Hardcover ISBN: 978-3-642-33720-8Published: 02 March 2013

  • Softcover ISBN: 978-3-662-52320-9Published: 23 August 2016

  • eBook ISBN: 978-3-642-33721-5Published: 26 January 2013

  • Series ISSN: 1861-2253

  • Series E-ISSN: 1863-0685

  • Edition Number: 1

  • Number of Pages: XIII, 181

  • Topics: Neurosciences, Endocrinology, Human Genetics

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