Results and Problems in Cell Differentiation

Vertebrate Myogenesis

Stem Cells and Precursors

Editors: Brand-Saberi, Beate (Ed.)

  • Gives an overview of the latest findingsĀ on skeletal muscle development
  • Includes recent progress in muscle stem cell biology
  • Written by international experts in the field
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  • ISBN 978-3-662-44608-9
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Hardcover $209.00
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  • ISBN 978-3-662-44607-2
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Softcover $209.00
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  • ISBN 978-3-662-51318-7
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About this book

This book addresses the differentiation control of skeletal muscle in different locations of the vertebrate body Particular attention is paid to novel regulatory molecules and signals as well as the heterogeneity of origin that have revealed a developmental overlap between skeletal and cardiac muscle. Different functional muscle groups are the product of the evolution of the vertebrate classes, making a phylogenetic comparison worthwhile for understanding the role of muscle stem cells and precursors in myogenesis. New insights into the hierarchy of transcription factors, particularly in the context of these different muscle groups have been gained from detailed investigations of the spatio-temporal and regulatory relationships derived from mouse and zebrafish genetics and avian microsurgery. Importantly, epigenetic mechanisms that have surfaced recently, in particular the role of MyomiRs, are also surveyed.

With an eye to the human patient, encouraging results have been generated that identify parallels between embryonic myogenesis and regenerating myofibers due to common regulatory molecules. On the other hand, both processes differ considerably in quality and complexity of the processes employed. Interestingly, the heterogeneity in embryonic sources from which skeletal muscle groups in the vertebrate including the human body take origin is paralleled by differences in their susceptibility to particular muscle dystrophies as well as by the characteristics of the satellite cells involved in regeneration. The progress that has been made in the field of muscle stem cell biology, with special focus on the satellite cells, is outlined in this book by experts in the field. The authors review recent insights of the heterogeneous nature of these satellite cells regarding their gene signatures and regeneration potential. Furthermore, an improved understanding of muscle stem cells seems only possible when we study the impact of the cell environment on efficient stem cell replacement therapies for muscular dystrophies, putting embryological findings from different vertebrate classes and stem cell approaches into context.

Table of contents (10 chapters)

  • Recruitment of Skeletal Muscle Progenitors to Secondary Sites: A Role for CXCR4/SDF-1 Signalling in Skeletal Muscle Development

    Masyuk, Maryna (et al.)

    Pages 1-23

  • Hypaxial Muscle: Controversial Classification and Controversial Data?

    Wotton, Karl R. (et al.)

    Pages 25-48

  • Skeletal Myogenesis in the Zebrafish and Its Implications for Muscle Disease Modelling

    Gurevich, David (et al.)

    Pages 49-76

  • Mechanisms of Myogenic Specification and Patterning

    Applebaum, Mordechai (et al.)

    Pages 77-98

  • The Avian Embryo as a Model System for Skeletal Myogenesis

    Hirst, Claire E. (et al.)

    Pages 99-122

Buy this book

eBook $159.00
price for USA (gross)
  • ISBN 978-3-662-44608-9
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $209.00
price for USA
  • ISBN 978-3-662-44607-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $209.00
price for USA
  • ISBN 978-3-662-51318-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Vertebrate Myogenesis
Book Subtitle
Stem Cells and Precursors
Editors
  • Beate Brand-Saberi
Series Title
Results and Problems in Cell Differentiation
Series Volume
56
Copyright
2015
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-662-44608-9
DOI
10.1007/978-3-662-44608-9
Hardcover ISBN
978-3-662-44607-2
Softcover ISBN
978-3-662-51318-7
Series ISSN
0080-1844
Edition Number
1
Number of Pages
VI, 242
Number of Illustrations and Tables
2 b/w illustrations, 23 illustrations in colour
Topics