Long Circulating Liposomes: Old Drugs, New Therapeutics

1. Front Matter

   Pages i-xx

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2. Introduction

   1. Front Matter

      Pages 1-1

      PDF

   2. Long Circulating Liposome Therapeutics: From Concept to Clinical Reality

      • Gerrit Storm, Martin C. Woodle

      Pages 3-16

3. Current Medical Applications

   1. Front Matter

      Pages 17-17

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   2. Malignant Diseases

      1. Oncologic Agents in Sterically Stabilized Liposomes: Basic Considerations

         • Theresa M. Allen

         Pages 19-28

      2. Liposomal Vincristine: The Central Role of Drug Retention in Defining Therapeutically Optimized Anticancer Formulations

         • Nancy L. Boman, Pieter R. Cullis, Lawrence D. Mayer, Marcel B. Bally, Murray S. Webb

         Pages 29-49

      3. Long Circulating Liposome-Encapsulated Tumor Necrosis Factor in the Treatment of Solid Tumors

         • Timo L. M. ten Hagen, Alexander H. van der Veen, Alexander M. M. Eggermont

         Pages 51-60

      4. Therapy of Human Carcinoma Xenografts with Doxorubicin Encapsulated in Sterically Stabilized Liposomes (DOXIL®): Efficacy and Safety Studies

         • Jan Vaage, Paul S. Uster, Peter K. Working

         Pages 61-72

      5. Design and Development of Long Circulating Liposomal Daunorubicin for In Vivo Targeting of Solid Tumors: DaunoXome®

         • Eric A. Forssen, Richard T. Proffitt

         Pages 73-96

      6. Enhancement of Doxorubicin by Encapsulation in Long Circulating Thermosensitive Liposomes Combined with Local Hyperthermia

         • Kazuo Maruyama

         Pages 97-109

      7. Liposomal Localization and Chemotherapy for AIDS-Related Kaposi’s Sarcoma

         • Mark Harrison, K. J. Harrington, J. S. W. Stewart

         Pages 111-125

      8. Pegylated-Liposomal Doxorubicin (Doxil®) in the Treatment of AIDS-Related Kaposi’s Sarcoma

         • Donald W. Northfelt

         Pages 127-145

      9. DaunoXome® (Liposomal Daunorubicin) for First-Line Treatment of Advanced, HIV-Related Kaposi’s Sarcoma

         • Geoffrey Mukwaya, Eric A. Forssen, Paul Schmidt, Michael Ross

         Pages 147-163

      10. Initial Clinical Evaluation of Pegylated-Liposomal Doxorubicin in Solid Tumors

          • Alberto A. Gabizon, Franco M. Muggia

          Pages 165-174

   3. Other Therapeutic Applications

      1. Antibacterial Therapy with Sterically Stabilized Liposome Formulations

         • Irma A. J. M. Bakker-Woudenberg, Gerrit Storm, Martin C. Woodle

         Pages 177-183

      2. AmBisome®: Long Circulating Liposomal Formulation of Amphotericin B

         • Jill P. Adler-Moore, Richard T. Proffitt

         Pages 185-206

      3. Steric Stabilization of Liposomes Containing Amphotericin B: A Future Direction in Antifungal Therapy?

         • Els W. M. van Etten, Irma A. J. M. Bakker

         Pages 207-211

      4. Clinical and Preclinical Studies with Low-Clearance Liposomal Amikacin (MiKasome®)

         • Robert M. Fielding, Geoffrey Mukwaya, Robert A. Sandhaus

         Pages 213-225

   4. Diagnostics

      1. Sterically Stabilized Liposomes to Image Infection and Inflammation

         • Otto C. Boerman, Wim J. G. Oyen, Frans H. M. Corstens, Gerrit Storm

         Pages 229-240

      2. Long Circulating Liposomes for Diagnostic Imaging

         • Vladimir S. Trubetskoy, Vladimir P. Torchilin

         Pages 241-255

This book provides an up-to-date evaluation of clinical aspects of newly available "long-circulating liposome" formulations. Based on results from numerous clinical studies, the book describes the fundamentals of this new technology, discusses how it may influence the pharmacology of existing well-known agents reformulated in this manner, and elaborates on future expectations. It provides the practicing clinician - in particular, oncologists and critical care infectious disease physicians - with the tools needed to use these new formulations towards the best outcome for the patient.

• Arzneimittel
• Liposomen
• Onkologie
• drug
• drug design
• fatty acids
• infectious disease
• influence
• lipide
• lipids
• liposomes
• oncology
• pharmaceutical
• pharmacology
• tumor

• Genetic Therapy, Inc., Gaithersburg, USA

  Martin C. Woodle

• Department of Pharmaceutics, University of Utrecht, Utrecht, The Netherlands

  Gerrit Storm

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