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  • Book
  • © 1997

Glycoproteins and Human Disease

Authors:

  1. Inka Brockhausen

    1. Department of Biochemistry Research Institute, Hospital for Sick Children, University of Toronto, Toronto, Canada

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    You can also search for this author in PubMed   Google Scholar

  2. William Kuhns

    1. Department of Biochemistry Research Institute, Hospital for Sick Children, University of Toronto, Toronto, Canada

    View author publications

    You can also search for this author in PubMed   Google Scholar

Part of the book series: Medical Intelligence Unit (MIU.LANDES)

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Table of contents (28 chapters)

  1. Front Matter

    Pages i-xiii
    PDF

  2. Abstract

    • Inka Brockhausen, William Kuhns
    Pages 1-1

  3. Introduction

    • Inka Brockhausen, William Kuhns
    Pages 3-4

  5. Biosynthesis of O-Glycans

    • Inka Brockhausen, William Kuhns
    Pages 13-31

  7. Biosynthesis of N-Glycans

    • Inka Brockhausen, William Kuhns
    Pages 37-46

  8. Less Common O-Linked Carbohydrates of Glycoproteins

    • Inka Brockhausen, William Kuhns
    Pages 47-49

  9. Control Mechanisms in the Biosynthesis of N- and O-Glycans

    • Inka Brockhausen, William Kuhns
    Pages 51-59

  10. Glycoproteins and Cell Adhesion Functions

    • Inka Brockhausen, William Kuhns
    Pages 61-75

  11. Role of Glycoproteins of the Immune and Blood Coagulation Systems

    • Inka Brockhausen, William Kuhns
    Pages 77-84

  13. General Glycoprotein Functions

    • Inka Brockhausen, William Kuhns
    Pages 99-107

  14. Glycosylation in Leukemia and Blood-Related Disorders

    • Inka Brockhausen, William Kuhns
    Pages 109-120

  15. Glycosylation in Cystic Fibrosis

    • Inka Brockhausen, William Kuhns
    Pages 121-126

  16. Inflammatory Diseases

    • Inka Brockhausen, William Kuhns
    Pages 127-131

  17. Carbohydrate Deficiency Diseases

    • Inka Brockhausen, William Kuhns
    Pages 133-139

  18. Microorganisms

    • Inka Brockhausen, William Kuhns
    Pages 141-150

  19. Glycoproteins in Degenerative Disease and Xenograft Rejection

    • Inka Brockhausen, William Kuhns
    Pages 151-155

  20. Glycosylation in Cancer and Oncogenic Transformation

    • Inka Brockhausen, William Kuhns
    Pages 157-173
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About this book

Diverse alterations of glycosylation occur in diseases such as cancer, metastasis, leukemia, inflammatory and other diseases. The glycosylation abnormalities found in disease are the result of complex rearrangements of the oligosaccharide assembly by glycosyltransferases. This volume reviews several mechanisms that may underly the extremely complex alterations in disease. Disease specific glycosylation may contribute to the disease process by altering cellular functions, or may be exploited therapeutically. Specific therapy may be aimed at correcting glycosylation abnormalities based on knowledge of the mechanisms leading to the disease phenotype and the three-dimensional interactions between carbohydrates and carbohydrate-binding molecules.
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Keywords

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Authors and Affiliations

  • Department of Biochemistry Research Institute, Hospital for Sick Children, University of Toronto, Toronto, Canada

    Inka Brockhausen, William Kuhns

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Bibliographic Information

  • Book Title: Glycoproteins and Human Disease

  • Authors: Inka Brockhausen, William Kuhns

  • Series Title: Medical Intelligence Unit

  • DOI: https://doi.org/10.1007/978-3-662-21960-7

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1997

  • Softcover ISBN: 978-3-662-21962-1Published: 17 April 2014

  • eBook ISBN: 978-3-662-21960-7Published: 21 November 2013

  • Series ISSN: 1080-3645

  • Edition Number: 1

  • Number of Pages: XIII, 242

  • Number of Illustrations: 5 b/w illustrations, 1 illustrations in colour

  • Additional Information: Jointly published with R.G. Landes. Biomedical Publishers, Austin, USA

  • Topics: Molecular Medicine

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Buy it now

eBook USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

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