Signaling Pathways for Translation

1. Front Matter

   Pages I-X

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2. The Regulation of eIF4F During Cell Growth and Cell Death

   • Simon J. Morley

   Pages 1-37

3. Regulation of the Activity of Eukaryotic Initiation Factors in Stressed Cells

   • Gert C. Scheper, Roel Van Wijk, Adri A. M. Thomas

   Pages 39-56

4. Initiation Factor eIF2α Phosphorylation in Stress Responses and Apoptosis

   • Michael J. Clemens

   Pages 57-89

5. Elongation Factor-2 Phosphorylation and the Regulation of Protein Synthesis by Calcium

   • Angus C. Nairn, Masayuki Matsushita, Kent Nastiuk, Atsuko Horiuchi, Ken-Ichi Mitsui, Yoshio Shimizu et al.

   Pages 91-129

6. Phosphorylation of Mammalian eIF4E by Mnk1 and Mnk2: Tantalizing Prospects for a Role in Translation

   • Malathy Mahalingam, Jonathan A. Cooper

   Pages 131-142

7. Control of Translation by the Target of Rapamycin Proteins

   • Anne-Claude Gingras, Brian Raught, Nahum Sonenberg

   Pages 143-174

8. Back Matter

   Pages 175-176

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This volume presents the response of the eukaryotic translational apparatus to cellular stress and apoptosis, including kinases activated through both the ERK and stress-activated pathways. It further explores two agents that inhibit protein synthesis, calcium and the immunosuppressant rapamycin. Six chapters written by leading experts in the field provide both new data and comprehensive literature reviews. Both the regulation of initiation and elongation are discussed, and the mechanisms of apoptosis are related to changes in the protein synthesis machinery.

• Calcium
• Endoplasmatisches Reticulum
• Rapamycin
• Ribosomen
• Zelltod
• apoptosis
• cell
• cell death
• phosphorylation
• protein
• protein synthesis
• proteins
• regulation
• synthesis
• translation

• Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, USA

  Robert E. Rhoads

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