Nato ASI Subseries H:

Activation and Desensitization of Transducing Pathways

Editors: Konijn, T.M., Houslay, Miles, Haastert, P.J.M. van (Eds.)

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  • ISBN 978-3-642-83618-3
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About this book

Activation by and desensitization to signals originating from the environment is common in all organisms, ranging from prokaryotes to higher eukaryotes. Recently, a number of novel mechanisms involved in activation and desensitization have been elucidated. The similarities of the molecular mechanisms of activation and desensitization in the various systems are striking. In the first book (1987) on this topic, the functional and structural similarities of the various mechanisms to attenuate the effect of an outward signal were emphasized. Justification to have a second book three years later is the explosive growth of information in the field. More components involved in signal transfer have been discovered and also that several more G-proteins appear to play a role during this process. The interest in signal attenuation concurs with these developments. The emphasis in this book is on the common signal transfer elements responsible for activation and desensitization in animals, plants and microorganisms.

Table of contents (19 chapters)

  • Activation and Densensitization in Bacterial Chemotaxis

    Simon, Melvin I.

    Pages 3-21

  • Adaptation of Chemoattractant Elicited Responses in Dictyostelium Discoideum

    Vaughan, Roxanne (et al.)

    Pages 23-40

  • The Inositolcycle of Dictyostelium Discoideum

    Haastert, Peter J. M. (et al.)

    Pages 41-59

  • Glucagon activates two distinct signal transduction systems in hepatocytes, which leads to the desensitization of G-protein-regulated adenylate cyclase, the phosphorylation and inactivation of Gi-2 and the phosphorylation and stimulation of a specific cyclic AMP phosphodiesterase

    Houslay, Miles D. (et al.)

    Pages 63-83

  • Multiple Pathways for Glucagon-Induced Heterologous Desensitization of Liver Adenylyl Cyclase

    Premont, Richard T. (et al.)

    Pages 85-97

Buy this book

eBook $109.00
price for USA (gross)
  • ISBN 978-3-642-83618-3
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $149.00
price for USA
  • ISBN 978-3-642-83620-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Activation and Desensitization of Transducing Pathways
Editors
  • T.M. Konijn
  • Miles Houslay
  • P.J.M. van Haastert
Series Title
Nato ASI Subseries H:
Series Volume
44
Copyright
1990
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-83618-3
DOI
10.1007/978-3-642-83618-3
Softcover ISBN
978-3-642-83620-6
Series ISSN
1010-8793
Edition Number
1
Number of Pages
XI, 320
Topics