Molecular Biology, Biochemistry and Biophysics Molekularbiologie, Biochemie und Biophysik

ADP-Ribosylation of Proteins

Enzymology and Biological Significance

Authors: Althaus, Felix R., Richter, Christoph

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About this book

In 1966, a paper entitled "On the formation of a novel adenylylic compound by enzymatic extracts of liver nuclei" from Paul Mandel's laboratory in Strasbourg, France, planted the seed for a rapidly growing new field of biological research focusing on ADP-ribosylation reactions. The development of this field over the past 2 decades reflects very much a modern trend of biological research. As more detailed knowledge accumulates, enigmatic phenomena turn into concepts which create their own enigmata. This process tends to favor the development of multiple, seemingly disconnected, research lines until simplicity emerges from chaos and unifying concepts substitute for controversy. It appears that the field of ADP-ribosylation reactions has not yet attained this latter stage. For example, with the identification of two different classes of ADP-ribosylation reactions, i.e., mono-ADP-ribosyla­ tion and poly-ADP-ribosylation reactions, the field split very early into two separate branches of research. With the present volume, we have divided the task of reviewing these two classes of ADP­ ribosylation accordingly, although their coexistence in eukaryotes may involve a closer functional linkage than hitherto recognized.

Table of contents (16 chapters)

  • Poly(ADP-Ribose): Structure, Properties and Quantification

    Althaus, Felix R. (et al.)

    Pages 3-11

  • Poly(ADP-Ribose) Biosynthesis

    Althaus, Felix R. (et al.)

    Pages 12-37

  • Poly(ADP-Ribose) Catabolism

    Althaus, Felix R. (et al.)

    Pages 38-44

  • Nuclear Acceptor Proteins for Poly(ADP-Ribose) and the Functional Consequences of Poly-ADP-Ribosylation on the Acceptor Species

    Althaus, Felix R. (et al.)

    Pages 45-58

  • Poly-ADP-Ribosylation and Chromatin Organization

    Althaus, Felix R. (et al.)

    Pages 59-65

Buy this book

eBook $109.00
price for USA (gross)
  • ISBN 978-3-642-83077-8
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $149.00
price for USA
  • ISBN 978-3-642-83079-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
ADP-Ribosylation of Proteins
Book Subtitle
Enzymology and Biological Significance
Authors
Series Title
Molecular Biology, Biochemistry and Biophysics Molekularbiologie, Biochemie und Biophysik
Series Volume
37
Copyright
1987
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-83077-8
DOI
10.1007/978-3-642-83077-8
Softcover ISBN
978-3-642-83079-2
Series ISSN
0077-0221
Edition Number
1
Number of Pages
XVI, 238
Topics