Overview
- Authors:
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Felix R. Althaus
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Institut für Pharmakologie und Biochemie, Universität Zürich, Zürich, Germany
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Christoph Richter
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Laboratorium für Biochemie, ETH-Zentrum, Zürich, Germany
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Table of contents (16 chapters)
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Poly-ADP-Ribosylation Reactions
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- Felix R. Althaus, Christoph Richter
Pages 3-11
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- Felix R. Althaus, Christoph Richter
Pages 12-37
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- Felix R. Althaus, Christoph Richter
Pages 38-44
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- Felix R. Althaus, Christoph Richter
Pages 45-58
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- Felix R. Althaus, Christoph Richter
Pages 59-65
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- Felix R. Althaus, Christoph Richter
Pages 66-92
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- Felix R. Althaus, Christoph Richter
Pages 93-100
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- Felix R. Althaus, Christoph Richter
Pages 101-113
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- Felix R. Althaus, Christoph Richter
Pages 114-125
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Mono-ADP-Ribosylation Reactions
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Front Matter
Pages 127-130
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- Felix R. Althaus, Christoph Richter
Pages 131-139
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- Felix R. Althaus, Christoph Richter
Pages 140-154
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- Felix R. Althaus, Christoph Richter
Pages 155-182
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- Felix R. Althaus, Christoph Richter
Pages 183-194
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- Felix R. Althaus, Christoph Richter
Pages 195-208
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- Felix R. Althaus, Christoph Richter
Pages 209-215
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- Felix R. Althaus, Christoph Richter
Pages 216-230
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Back Matter
Pages 231-237
About this book
In 1966, a paper entitled "On the formation of a novel adenylylic compound by enzymatic extracts of liver nuclei" from Paul Mandel's laboratory in Strasbourg, France, planted the seed for a rapidly growing new field of biological research focusing on ADP-ribosylation reactions. The development of this field over the past 2 decades reflects very much a modern trend of biological research. As more detailed knowledge accumulates, enigmatic phenomena turn into concepts which create their own enigmata. This process tends to favor the development of multiple, seemingly disconnected, research lines until simplicity emerges from chaos and unifying concepts substitute for controversy. It appears that the field of ADP-ribosylation reactions has not yet attained this latter stage. For example, with the identification of two different classes of ADP-ribosylation reactions, i.e., mono-ADP-ribosyla tion and poly-ADP-ribosylation reactions, the field split very early into two separate branches of research. With the present volume, we have divided the task of reviewing these two classes of ADP ribosylation accordingly, although their coexistence in eukaryotes may involve a closer functional linkage than hitherto recognized.
Authors and Affiliations
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Institut für Pharmakologie und Biochemie, Universität Zürich, Zürich, Germany
Felix R. Althaus
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Laboratorium für Biochemie, ETH-Zentrum, Zürich, Germany
Christoph Richter