Molecular Biology, Biochemistry and Biophysics Molekularbiologie, Biochemie und Biophysik

Inhibitors of Nucleic Acid Synthesis

Biophysical and Biochemical Aspects

Authors: Kersten, H., Kersten, W.

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About this book

During the last decade physical and chemical methods have improved rapidly - a fact which allowed the mode of action of antibiotics to be studied - and many biochemically-oriented scientists have devoted their research to the following questions: 1. What is the metabolic pathway that is inhibited selectively, and what are the target molecules within a sensitive cell? 2. What are the relationships between the chemical structure of an antibiotic and the physicochemical properties of the sensitive moleĀ­ cule(s)? 3. Why and how far is the action selective? 4. Is it possible to correlate the interaction with the target moleĀ­ cule(s) with the particular biological activities observed? This monograph deals with those antibiotics which interfere with the biosynthesis of nucleic acids. The idea was to provide an insight into how to investigate the preceding questions experimentally and to solve as yet unresolved problems rather than to give a review of the current state of knowledge. Although the biochemistry of nucleic acid synthesis is known in general, the precise molecular mechanisms by which deoxyribonucleic acid is replicated or transcribed has still to be clarified. For this reason it is not yet possible to describe the molecular mechanisms by which the inhibitors of nucleic acid and protein synthesis exhibit their effects. The fact that the inhibitors of nucleic acid and protein synthesis themselves served as useful tools to obtain an insight into the mechanisms of replication, transcription and translation was one of the most exciting discoveries in this field.

Table of contents (5 chapters)

  • General Introduction

    Kersten, Helga (et al.)

    Pages 1-2

  • Inhibitors of DNA Synthesis

    Kersten, Helga (et al.)

    Pages 3-39

  • Inhibitors of RNA Synthesis that Interact with the DNA Template

    Kersten, Helga (et al.)

    Pages 40-106

  • Inhibitors of RNA Synthesis Interacting with RNA Polymerases

    Kersten, Helga (et al.)

    Pages 107-126

  • Inhibitors Interferring at the Precursor Level or with Regulatory Processes of Nucleic Acid Synthesis

    Kersten, Helga (et al.)

    Pages 127-139

Buy this book

eBook $109.00
price for USA (gross)
  • ISBN 978-3-642-80855-5
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $149.00
price for USA
  • ISBN 978-3-642-80857-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Inhibitors of Nucleic Acid Synthesis
Book Subtitle
Biophysical and Biochemical Aspects
Authors
Series Title
Molecular Biology, Biochemistry and Biophysics Molekularbiologie, Biochemie und Biophysik
Series Volume
18
Copyright
1974
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-80855-5
DOI
10.1007/978-3-642-80855-5
Softcover ISBN
978-3-642-80857-9
Series ISSN
0077-0221
Edition Number
1
Number of Pages
X, 186
Topics