Gut Dysfunction in Critical Illness

1. Front Matter

   Pages I-XII

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2. Gastrointestinal Structure and Function

   1. Front Matter

      Pages 2-2

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   2. Pathophysiology of Gut Dysfunction in Shock and Sepsis

      • U. Haglund

      Pages 3-11

   3. Intestinal Mucosal Hyperpermeability in Critical Illness

      • M. P. Fink

      Pages 12-24

   4. Molecular Mechanisms of Intestinal Injury, Repair, and Growth

      • T. R. Ziegler

      Pages 25-52

   5. Regulation of Gut Perfusion

      • B. Cholley, D. Payen

      Pages 53-64

   6. Regulation of Gut Oxygen Delivery, Cellular Oxygen Supply and Metabolic Activity

      • P. T. Schumacker

      Pages 65-75

   7. Immunology of the Gut

      • L. D. McVay

      Pages 76-101

   8. Mast Cells and Neutrophils in Intestinal Ischemia/Reperfusion

      • P. Kubes

      Pages 102-113

   9. Clinical Markers of Gastrointestinal Dysfunction

      • J. C. Marshall

      Pages 114-128

3. Bacterial Translocation

   1. Front Matter

      Pages 129-129

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   2. Bacterial Translocation: Intestinal Epithelial Permeability

      • C. L. Wells, S. L. Erlandsen

      Pages 131-149

   3. Is Bacterial Translocation Clinically Relevant?

      • H. Redl, S. Bahrami, G. Schlag

      Pages 150-163

   4. Experimental Multiple Organ Failure and Gut Dysfunction

      • R. J. A. Goris, G. A. P. Nieuwenhuijzen, M. M. J. Jansen

      Pages 164-176

   5. Intestinal Cytokines

      • J. Carlet, F. Tamion, A. Cabie

      Pages 177-188

   6. Selective Decontamination of the Digestive Tract

      • C. P. Stoutenbeek, H. K. F. van Saene

      Pages 189-201

   7. Increased Gastrointestinal Permeability

      • D. G. Sinclair, T. W. Evans

      Pages 202-216

   8. Gut Dysfunction in Trauma Patients

      • F. A. Moore, E. E. Moore

      Pages 217-229

4. Gut Perfusion

   1. Front Matter

      Pages 231-231

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   2. Gastrointestinal Mucosal Ischemia

      • B. Vallet, R. Nevière, J. L. Chagnon

      Pages 233-245

Dysfunction of the gastrointestinal tract in critically ill patients has recently become a focus of intensive research. This book, the first one on this topic, is a comprehensive overview of what is currently known about the role of the gut in patients requiring intensive care. The definitions and pathogenesis of intestinal dysfunction are critically evaluated. Currently available and potential new ways to monitor intestinal function in the intensive care setting are presented. Emphasis has been placed on the evaluation of therapeutic strategies in the prevention and treatment of gut dysfunction. Options for monitoring and treating gut dysfunction in critically ill patients are rapidly evolving. This volume provides state-of-the-art information for both clinicians and clinical researchers.

• Sepsis
• Trauma
• care
• growth
• immunology
• intensive care
• multiple organ failure
• nutrition
• pathophysiology
• physiology
• prevention
• shock

• Department of Surgery, Pennsylvania University Hospital, Philadelphia, USA

  J. L. Rombeau

• Department of Intensive Care Critical Care Research Program, Kuopio University Hospital, Kuopio, Finland

  J. Takala

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