Signalling Mechanisms — from Transcription Factors to Oxidative Stress

1. Front Matter

   Pages I-X

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2. Components of Signal Transduction

   1. The [Ca2+]i Concept: from whole Cell to Microdomains

      • Jacopo Meldolesi, Fabio Grohovaz

      Pages 1-10

   2. Versatile functions of Ca2+-binding proteins in signal transduction and Ca2+ homeostasis

      • T. L. Pauls

      Pages 11-21

   3. Purification of a neurite growth inhibitor (NI-250) from bovine CNS myelin

      • Adrian A. A. Spillmann, Christine E. Bandtlow, Flavio Keller, Martin E. Schwab

      Pages 23-28

   4. Protein Kinase C and Lipid Signalling for Cellular Regulation

      • Shun-ichi Nakamura, Kouji Ogita, Yasutomi Nishizuka, Yoshinori Asaoka, Françoise Hullin

      Pages 29-47

   5. Phospholipase D Regulation in Relationship with Several Protein Kinases Activation in Human Neutrophil

      • Valérie Planat, Jean-Marc Lanau, Michel Record, Hugues Chap

      Pages 49-55

   6. Phosphatidic Acid Phosphohydrolase: Its Role in Cell Signalling

      • Ian N. Fleming, Stephen J. Yeaman

      Pages 57-64

   7. A Novel Form of Type-IVA cAMP Phosphodiesterase found in rat brain

      • Linda Pooley, Miles D. Houslay

      Pages 65-76

   8. Interaction of the Retinal Cyclic Gmp-Phosphodiesterase Inhibitor with Transducin (Gt) and with Other G-Proteins (Gi, Go and Gs)

      • Annie Otto-Bruc, Bruno Antonny, Marc Chabre, Pierre Chardin, Eva Faurobert, T. Minh Vuong

      Pages 77-85

   9. Identification of stable opioid receptor Go-protein complexes using GTP-binding protein selective antisera

      • Zafiroula Georgoussi, Graeme Milligan, Christine Zioudrou

      Pages 87-98

   10. The Use of Stably Transfected Cell Lines in the Analysis of Functional Interactions between Goα1 & Giα2 and the α2C10 Adrenoceptor

       • Morag A. Grassie, Graeme Milligan

       Pages 99-113

   11. Modulation of the Ampa/Kainate Receptors by Protein Kinase C

       • Carlos B. Duarte, Ana L. Carvalho, Arsélio P. Carvalho

       Pages 115-124

   12. Interaction of MARCKS, a major protein kinase C substrate, with the membrane

       • Guy Vergères, Stéphane Manenti, Thomas Weber

       Pages 125-137

   13. Phosphorylase Kinase: A Protein Kinase For All Seasons

       • Theodore G. Sotiroudis, George A. Maridakis, Anna-Maria G. Psarra, Athanassios E. Evangelopoulos

       Pages 139-156

3. Antioxidants, Oxidative Stress and Hypoxia

   1. Signal, Messenger and Trigger Molecules from Free Radical Reactions and their Control by Antioxidants

      • John M. C. Gutteridge

      Pages 157-164

   2. Strategies of Antioxidant Defense: Relations to Oxidative Stress

      • Helmut Sies

      Pages 165-186

   3. Antioxidants: Molecular Interactions Between Vitamins E And C, Biothiols and Carotenes

      • Lester Packer

      Pages 187-216

   4. Biokinetics of Vitamin E in Lipoproteins and Cells

      • Maret G. Traber

      Pages 217-228

   5. Role of Mitochondria in Radical Generation and Toxicity of τ-Butylhydroperoxide Towards Cultured Human Endothelial Cells

      • Valerie B. O’Donnell, Mark J. Burkitt, Jonathan D. Wood

      Pages 229-240

   6. Hypoxia and Endothelial Cell Adhesiveness

      • Anneke Pietersma, Netty de Jong, Johan F. Koster, Wim Sluiter

      Pages 241-250

A NATO Advanced Study Institute on "Molecular Mechanisms of Transcellular Signaling: from the Membrane to the Gene" was held on the Island of Spetsai, Greece, from August 15- 27, 1994. The aim of this Institute was to bring together researchers in the field of signal transduction mechanisms, transcription factors and gene regulation with those actively involved in studies on the implications of oxygen radicals and antioxidant defence mechanisms for cell function. As diverse as these fields may be, the emergence of their interconnection during the course of the Institute was an eye-opener for students and lecturers alike. 2 Presentations and discussions focussed on the role of Ca +, G-proteins, protein kinase C and phospholipases in signaling mechanisms. These broad principles were extended to transcription factors and gene regulation with an emphasis on the steroid hormone receptor superfamily and NFKB. Basic principles of free radical formation and antioxidant action (vitamin E and C) were presented and discussed in connection with effects on signaling pathways. This book present the content of the major lectures and a selection of the most relevant posters. These proceedings offer a comprehensive account of the most important topics discussed at the Institute. The book is intended to make the proceedings accessible to a large audience.

• Calcium
• Signalübertragung
• Transkriptionsfaktoren
• antioxidant
• cell
• cell nucleus
• cells
• defense mechanism
• gen regulation
• gene
• oxidative stress
• protein
• signal transduction
• transcription
• transcription factors

• Department of Molecular and Cell Biology, University of California, Berkeley, USA

  Lester Packer

• Centre for Biomembranes and Lipid Enzymology, Utrecht University, Utrecht, The Netherlands

  Karel W. A. Wirtz

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