Current Topics in Microbiology and Immunology

ADP-Ribosylating Toxins

Editors: Aktories, Klaus (Ed.)

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About this book

ADP-ribosylating toxins have been the focus of intensive research for more than 30 years. Researchers from diverse fields of science have taken an interest in these bacterial toxins; they are studied, for example, by microbiologists, biochemists, cell biologists, and pharmacologists. There are two principal reasons for the broad and still growing interest in ADP­ ribosylating toxins. First, insights into the structure and functions of the toxins might be the key to prevention and treatment of diseases caused by the toxin-producing infectious micro­ organisms. Second, the ADP-ribosylating toxins provide potent and often unique pharmacological tools for the study of the physiological functions of their target proteins. The latter is especially the case with cholera and pertussis toxins, which both modify the IX-subunits of heterotrimeric G-proteins involved in signal transduction pathways. These toxins have proved invaluable in extending our basic understanding of the regulation of hormone-controlled signal transduction. This volume provides a review and an update of recent studies on the basic properties of bacterial ADP-ribosylating tbxins and/or exoenzymes. Our current knowledge of the cel­ lular entry mechanisms of ADP-ribosylating toxins is reviewed by MADSHUS and STENMARK. WILSON and COLLIER then deal with recent insights into the enzyme mechanism and active site structure of diphtheria toxin and Pseudomonas aeruginosa exotoxin A, which modify elongation factor 2. Toxins which ADP-ribosylate heterotrimeric G-proteins involved in trans­ membrane signal transduction are the subject of the next two chapters.

Table of contents (7 chapters)

  • Entry of ADP-Ribosylating Toxins into Cells

    Madshus, I. H. (et al.)

    Pages 1-26

  • Diphtheria Toxin and Pseudomonas aeruginosa Exotoxin A: Active-Site Structure and Enzymic Mechanism

    Wilson, B. A. (et al.)

    Pages 27-41

  • Enhancement of Cholera Toxin-Catalyzed ADP-Ribosylation by Guanine Nucleotide-Binding Proteins

    Serventi, I. M. (et al.)

    Pages 43-67

  • ADP-Ribosylation of Signal-Transducing Guanine Nucleotide-Binding Proteins by Pertussis Toxin

    Gierschik, P.

    Pages 69-96

  • Clostridial Actin-ADP-Ribosylating Toxins

    Aktories, K. (et al.)

    Pages 97-113

Buy this book

eBook $109.00
price for USA (gross)
  • ISBN 978-3-642-76966-5
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $149.00
price for USA
  • ISBN 978-3-642-76968-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
ADP-Ribosylating Toxins
Editors
  • Klaus Aktories
Series Title
Current Topics in Microbiology and Immunology
Series Volume
175
Copyright
1992
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-76966-5
DOI
10.1007/978-3-642-76966-5
Softcover ISBN
978-3-642-76968-9
Series ISSN
0070-217X
Edition Number
1
Number of Pages
X, 148
Number of Illustrations and Tables
10 b/w illustrations
Topics