Nato ASI Subseries H:

Tin-Based Antitumour Drugs

Editors: Gielen, Marcel (Ed.)

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About this book

Whereas platinum compounds are already clinically used as anticancer agents, tin compounds exhibiting high enough antitumour activity have not yet been found to enter the clinical phase. This is paradoxical with the observation that 50% of the tested compounds showed some activity, which is an abnormally high percentage. This is probably due to the fact that research of this type with tin compounds started more recently than with platinum compounds and that almost exclusively known compounds coming from laboratories working in the field of organotin compounds have been blindly tested. Some research directed towards the development of organotin compounds with some biologically favourable properties, for instance derivatives with hydrophilic or lipophilic, or with increased bio-availability characteristics, has started only recently. We thought that was now the appropriate time to bring together experts from different disciplines (biochemists, pharmacologists, organotin chemists, oncologists, etc.) working in the field of tin-based antitumour drugs, to contribute to the critical assessment of existing knowledge in this new important topic, to identify the directions for future research and to promote close working relations between the different countries and professional experiences gathered in this workshop.

Table of contents (8 chapters)

  • The Role of Non-Platinum Complexes in Cancer Therapy

    Keppler, B. K.

    Pages 1-68

  • Tin Compounds and their Potential as Pharmaceutical Agents

    Crowe, Alan J.

    Pages 69-114

  • The Role of Tin Hormones in Senescence: A Hypothesis

    Cardarelli, Nate F.

    Pages 115-146

  • The Speciation and Bioavailability of Tin in Biofluids

    Duffield, J. R. (et al.)

    Pages 147-167

  • Cellular interactions of organotin compounds in relation to their antitumor activity

    Penninks, André H. (et al.)

    Pages 169-190

Buy this book

eBook $74.99
price for USA (gross)
  • ISBN 978-3-642-74191-3
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $99.00
price for USA
  • ISBN 978-3-642-74193-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Tin-Based Antitumour Drugs
Editors
  • Marcel Gielen
Series Title
Nato ASI Subseries H:
Series Volume
37
Copyright
1990
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-74191-3
DOI
10.1007/978-3-642-74191-3
Softcover ISBN
978-3-642-74193-7
Series ISSN
1010-8793
Edition Number
1
Number of Pages
VIII, 226
Number of Illustrations and Tables
3 b/w illustrations
Topics