Nato ASI Subseries H:

Host-Parasite Cellular and Molecular Interactions in Protozoal Infections

Editors: Chang, K.-P., Snary, David (Eds.)

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About this book

Tropical diseases such as leishmaniasis, malaria. trypanosomiasis, toxoplasmosis and amebiasis continue to plague the world, resulting in considerable morbidity and mortality, especially in the third world countries. These diseases are caused by a group of protozoa which have, over the years, undergone evolutionary adaptation to live often intracellularly in a parasitic way of life. So well-adapted have they become that they recognize the right hosts or cells to parasitize, yet at the same time they escape recognition and destruction by the host immune system. The mechanisms of such recognition and the escape of recognition are governed largely by host-parasite surface membrane interactions at the cellular and molecular level. Unique molecules produced by unusual pathways of these parasites have also been discovered and found to play important roles in their survival in the host. Understanding these mechanisms and pathways is essential not only to formulate a rational strategy for chemo- and immuno-prophylaxis and -therapy but also to unravel the mystery of biological evolution in symbiosis and parasitism. In the advent of our knowledge on the molecular biology and biochemistry of parasite membrane and other molecules, it is opportune to examine and discuss their possible roles in host-parasite recognition and interaction in a comparative approach. To highlight the recent advances of this area in various host-parasite systems, a NATO advanced Research Workshop was held from September 27 to October 1, 1986 at Hotel Villa del Mare, Acquafredda di Maratea, Italy.

Table of contents (48 chapters)

  • Pattern of Variant Surface Glycoprotein Coating in Nascent Metacyclic Trypanosoma Brucei in the Salivary Glands of Glossina Morsitans

    Vickerman, K. (et al.)

    Pages 1-8

  • Evolution of Antigenic Variation in African Trypanosomes

    Boothroyd, John C. (et al.)

    Pages 9-18

  • Structural Studies on the Glycophospholipid Membrane Anchor of Trypanosoma Brucei Variant Surface Glycoprotein

    Ferguson, M. A. J. (et al.)

    Pages 19-28

  • Metabolism of Trypanothione and Glutathionylspermidine in Trypanosomatids

    Fairlamb, Alan H. (et al.)

    Pages 29-40

  • Differentiation of Trypanosoma brucei from Bloodstream to Procyclic Trypomastigotes

    Overath, Peter (et al.)

    Pages 41-49

Buy this book

eBook $109.00
price for USA (gross)
  • ISBN 978-3-642-72840-2
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $149.00
price for USA
  • ISBN 978-3-642-72842-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Host-Parasite Cellular and Molecular Interactions in Protozoal Infections
Editors
  • K.-P. Chang
  • David Snary
Series Title
Nato ASI Subseries H:
Series Volume
11
Copyright
1987
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-72840-2
DOI
10.1007/978-3-642-72840-2
Softcover ISBN
978-3-642-72842-6
Series ISSN
1010-8793
Edition Number
1
Number of Pages
XIX, 425
Topics