Nato ASI Subseries H:

Gene Therapy

Editors: Xanthopoulos, Kleanthis G. (Ed.)

  • A comprehensive treatise of molecular and clinical aspects of gene therapy

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  • ISBN 978-3-642-72160-1
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About this book

Gene therapy has generated enormous expectations as it holds a great promise, namely to revolutionize clinical and molecular medicine. This is because the successful introduction of a gene sequence in somatic sells followed by long-term expression at therapeutic levels can fundamentally correct a variety of human disease such as inherited and acquired disorders, cancer and AIDS. The proceedings of the first ASI on Gene Therapy that took place from August 17-28, 1997 on the island of Spetsai, Greece, summarizes recent advances in the field as presented elegantly by the intemationally­ recognized experts that served as faculty at the meeting. Their contributions constitute brief but comprehensive reviews presented as independent chapters in this book and emphasize the influence of chromatin structure on gene expression, describe the principal mechanisms of gene expression, followed by articles on epigenic elements, viral vectors, non-viral vectors as gene delivery systems, animal models of human diseases, inducible regulatory systems, gene therapy of cancer, AIDS, monogenic disorders and ongoing clinical trials. Gene therapy is the logical progression to human health management because it offers a potential low cost and efficient treatment. Gene therapy can reach it's full potential and satisfy all expectations. However, a number of critical technology advancements need to be completed. These include the development of vectors capable of safe and efficient gene transfer, the control of cell type targeting and regulation of trans gene expression levels.

Table of contents (22 chapters)

  • A Few Glances at the Function of Chromatin and Nuclear Higher-Order Structure in Transcription Regulation

    Mirkovitch, Jovan

    Pages 1-16

  • Transcriptional Regulation and Gene Expression in the Liver

    Tomizawa, Minoru (et al.)

    Pages 17-36

  • Modeling Genetic Diseases in the Mouse

    Wynshaw-Boris, Anthony (et al.)

    Pages 37-44

  • The Use of Genetic Switches for the Generation of Conditional Mutants at the Level of Cells and Animals

    Bujard, Hermann

    Pages 45-52

  • Application of Tetracycline Regulatable Systems for Gene Therapy

    Bohl, Delphine (et al.)

    Pages 53-59

Buy this book

eBook $109.00
price for USA (gross)
  • ISBN 978-3-642-72160-1
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $149.00
price for USA
  • ISBN 978-3-642-72162-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Gene Therapy
Editors
  • Kleanthis G. Xanthopoulos
Series Title
Nato ASI Subseries H:
Series Volume
105
Copyright
1998
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-72160-1
DOI
10.1007/978-3-642-72160-1
Softcover ISBN
978-3-642-72162-5
Series ISSN
1010-8793
Edition Number
1
Number of Pages
VIII, 223
Topics