Current Topics in Microbiology and Immunology

Mechanisms in B-Cell Neoplasia

Workshop at the National Cancer Institute, National Institutes of Health, Bethesda, MD,USA,March 24–26,1986

Editors: Melchers, Fritz, Potter, Michael (Eds.)

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About this book

The fourth workshop on Mechanisms in B-Ce11 Neoplasia was held in Bethesda. Maryland. at the National Institutes of Health on March 24. 25 and 26. 1986. The meeting was attended by approximately 150 participants and 58 presentations were given. The purpose of these workshops and the yearly publications has been to provide a means for exchanging the rapidly developing information in this field and to bring maJor problems into focus. Edited trans­ cripts of the 1983 and 1985 workshops were published by Editiones Roche Bas1e, Switzerland. Papers brought to the 1984 workshop were published in Current Topics in Microbiology and Immunology, Vol. 113. Numerous retrovira1 recombinant viral constructs are now in general use in a variety of test systems, both in vivo and in vitro. These are proving to have interesting bio10gica1-prQperties. ------- Kecent1y developed systems for inducing B cell tumors are described: 1) The development of spontaneous ~-ce11 tumors in transgenic mice carrying deregulated ml£ genes and the Ig heavy chain promoter; 2) a method for inducing ·p1asmacytomas in BAL~/c mice with short latent periods of ca 70 days by infecting pristane treated mice with retroviruses carrying various types of deregulated ml£ genes; 3) induction of pre-B cell tumors with erbB containing recombinant retroviruses; 4) induction of B-ce11 and other tumors by infection of neonates with recombinant retroviruses. Several retrovira1 constructs containing ml£ sequences do not induce B-ce11 tumors in pristane conditioned mice •.

Table of contents (2 chapter)

  • Induction of Hematopoietic Tumors Using a Viral Construct Containing c-myc cDNA from Normal Mouse Spleen

    Linda Wolff, J. Frederic Mushinski, Eli Gilboa, et al.

    Pages 33-39

    Buy Chapter $29.95
  • A Growth-Factor Dependent B-Cell Hybridoma

    P. M. Lansdorp, L. A. Aarden, J. Calafat, W. P. Zeiljemaker

    Pages 105-113

    Buy Chapter $29.95
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Buy this book

eBook $99.00 net
( price for USA )
  • ISBN 978-3-642-71562-4
  • digitally watermarked, no DRM
  • included format: PDF
  • eBooks can be used on all Reading Devices
Softcover $129.00 net
( price for USA )
  • ISBN 978-3-642-71564-8
  • free shipping for individuals worldwide
  • usually dispatched within 3 to 5 business days

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Bibliographic Information

Bibliographic Information
Book Title
Mechanisms in B-Cell Neoplasia
Book Subtitle
Workshop at the National Cancer Institute, National Institutes of Health, Bethesda, MD,USA,March 24–26,1986
Series Title
Current Topics in Microbiology and Immunology
Series Volume
132
Copyright
1986
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-71562-4
DOI
10.1007/978-3-642-71562-4
Softcover ISBN
978-3-642-71564-8
Series ISSN
0070-217X
Edition Number
1
Topics