In Vitro Effects of Mineral Dusts

1. Front Matter

   Pages I-XIII

   PDF

2. Introduction

   1. Toxicity Testing of Mineral Dusts. Past. Present. Future

      • Jean Bignon

      Pages 1-6

3. Minerals and Target Cells

   1. Front Matter

      Pages 7-7

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   2. Role of Physicochemical Properties of Minerals

      1. Physicochemical Properties of Minerals Relevant to Biological Activities: State of the Art

         • A. M. Langer, R. P. Nolan

         Pages 9-24

      2. Surface Active Sites and Catalytic Properties of Asbestos Mineral. Possible Consequence for their Activity in Biological Medium

         • L. Bonneau, R. Zalma, J. Guignard, H. Pezerat, D. Mansuy, M. Fonecave

         Pages 25-30

      3. Investigations into the Mechanisms of Asbestos Toxicity

         • G. L. Fisher, K. L. McNeill, B. T. Mossman, J. Marsh, A. R. McFarland, R. W. Hart

         Pages 31-38

      4. Particle Size and Chemically-Induced Variability in the Membrolytic Activity of Quartz: Preliminary Observations

         • R. P. Nolan, A. M. Langer, K. W. Foster

         Pages 39-50

   3. Cellular Effects of Mineral Dusts

      1. The Target Cells for Inhaled Mineral Dusts

         • A. R. Brody, L. Hill

         Pages 53-58

      2. A Potential Role for Oxygen Radicals in Mineral Dust-Induced Lung Injury: Lessons from Lung Injury from Hyperoxia

         • J. E. Repine

         Pages 59-65

      3. Mechanisms of Toxic Injury by Asbestos Fibers: Role of Oxygen-Free Radicals

         • B. T. Mossman, J. P. Marsh

         Pages 66-74

      4. Release of Superoxide Anion and Hydrogen Peroxide by Macrophages in Response to Asbestos

         • K. Donaldson, J. Slight, R. E. Bolton

         Pages 75-81

      5. Stimulation of Neutrophil Chemiluminescence by Alveolar Macrophages from Patients Exposed to Asbestos

         • M. Bérardi, R. Bégin, M. Rola-Pleszczynski

         Pages 83-91

      6. Broncho Alveolar Lavage in Coal Worker’s Pneumoconiosis: Oxidant and Antioxidant Activities of Alveolar Macrophages

         • C. Voisin, B. Wallaert, C. Aerts, J. M. Grosbois

         Pages 93-100

      7. Summary and Synthesis of Part I. Role of Physico-Chemical Properties of Minerals (A)

         • J. Dunnigan, K. Robock

         Pages 101-102

      8. Summary and Synthesis of Part I. Cellular Effects of Mineral Dusts (B)

         • J. Dunnigan, A. Scharmann

         Pages 103-105

4. Immune Responses and Immunotoxicity

   1. Front Matter

      Pages 107-107

      PDF

   2. Immune Responses Induced by Mineral Dusts

      • R. P. Daniele

      Pages 109-119

   3. Effect of Asbestos Preparations on the Random Migration Pattern of Rabbit Alveolar Macrophages

      • Q. N. Myrvik

      Pages 121-127

   4. Inhaled Asbestos Fibers Produce Complement-Derived Chemotactic Factor(s) on Alveolar Surfaces

      • D. B. Warheit, G. George, L. H. Hill, R. Snyderman, A. R. Brody

      Pages 129-138

   5. Immunoregulation During Experimental Asbestosis

      • J. Stankova, S. Gouin, R. Bégin, M. Rola-Pleszczynski

      Pages 139-147

The Third International \~orkshop on "The in Vitro Effects of Mineral Dusts" was held on October 1 - 4, 1984 in Schluchsee, Black Forest, Federal Republic of Germany. In six sessions, 93 participants from 14 countries (USA 32, France 17, United Kingdom 12, FRG 11, Canada 9, Belgium 3, Hungary 1, Italy 2, India 1, Nether­ lands 1, Norway 1, Poland 1, Portugal 1, Turkey 1) treated and discussed the following subjects: - Significance of the physico-chemical properties of inhalable mineral dusts (mine dusts, asbestos, Man-Made Mineral Fibres - MMMF). - Cellular effects of inhalable mineral dusts with special regard to target ce 11 s. - Immune response and immune toxicity. - Carcinogenicity and interrelated genotoxic and non-genotoxic effects. - Effect of cell metabolism in combination with inflammation and fibrogenesis. - Significance and credibility of in vitro test systems. For the pathogenesis of biological effects and diseases caused by inhalable mineral dusts a number of factors may be significant such as: - Type of dust - Dose of dust - Size and shape of dust particles, and especially - Surface properties of dust particles, which inter alia determine the - sorption properties, e.g. for environmental substances.

• Dusts
• Minerals
• cell
• environment
• forest
• immune response
• metabolism
• pathogenesis
• ecotoxicology

• Hygiene-Institut, Universität Gießen, Gießen, Germany

  Ernst G. Beck

• Unité INSERM, CHU Henri Mondor, Creteil Cedex, France

  Jean Bignon

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