Handbook of Experimental Pharmacology

Pharmacology of Intestinal Permeation I

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About this book

The intestine, particularly the small bowel, represents a large surface (in the adult 2 human approximately 200m ) through which the body is exposed to its environment. A vigorous substrate exchange takes place across this large surface: nutrients and xenobiotics are absorbed from the lumen into the bloodstream or the lymph, and simultaneously, the same types of substrate pass back into the lumen. The luminal surface of the intestine is lined with a "leaky" epithelium, thus the passage of the substrates, in either direction, proceeds via both transcellular and intercellular routes. Simple and carrier-mediated diffusion, active transport, pinocytosis, phagocytosis and persorption are all involved in this passage across the intestinal wall. The term "intestinal permeation" refers to the process of passage of various substances across the gut wall, either from the lumen into the blood or lymph, or in the opposite direction. "Permeability" is the condition of the gut which governs the rate of this complex two-way passage. The pharmacologist's interest in the problem of intestinal permeation is twofold: on the one hand, this process determines thebioavailability of drugs and contributes significantly to the pharmacokinetics and toxicokinetics of xeno­ biotics; on the other hand, the pharmacodynamic effects of many drugs are manifested in a significant alteration of the physiological process of intestinal permeation.

Table of contents (17 chapters)

  • Morphology of the Intestinal Mucosa

    Carr, K. E. (et al.)

    Pages 1-50

  • Intestinal Permeation and Permeability: an Overview

    Csáky, T. Z.

    Pages 51-59

  • Permeability and Related Phenomena: Basic Concepts

    Capraro, V.

    Pages 61-89

  • Methods for Investigation of Intestinal Permeability

    Csáky, T. Z.

    Pages 91-111

  • Vascular Perfusion of Rat Small Intestine for Permeation and Metabolism Studies

    Windmueller, H. G. (et al.)

    Pages 113-156

Buy this book

eBook $109.00
price for USA (gross)
  • ISBN 978-3-642-69505-6
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $149.00
price for USA
  • ISBN 978-3-642-69507-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Pharmacology of Intestinal Permeation I
Series Title
Handbook of Experimental Pharmacology
Series Volume
70 / 1
Copyright
1984
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-69505-6
DOI
10.1007/978-3-642-69505-6
Softcover ISBN
978-3-642-69507-0
Series ISSN
0171-2004
Edition Number
1
Number of Pages
XX, 708
Topics