Current Topics in Microbiology and Immunology

The Molecular Biology of Adenoviruses I

30 Years of Adenovirus Research 1953–1983

Editors: Doerfler, W. (Ed.)

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About this book

A puzzling epidemiological problem was the driving force behind the discovery of human adenoviruses by Wallace Rowe and his colleagues 30 years ago. The de­ velopment of a plaque assay for poliomyelitis virus in 1953 led us to the threshold of quantitative virology, and in the same year the double-helical structure of DNA was discovered and became a cornerstone of mo­ lecular biology. The potential of adenoviruses as research tools in the molecular and cellular biology of eukaryotic cells was recognized as early as the late 1950s and early 1960s by several investigators. Structural and biochemical stu­ dies dominated the early years. In 1962, some of the adenoviruses were the first human viruses shown to be oncogenic in experimental animals. Thus adenovirology offered the investigator the entire gamut of host cell interactions, productive and abortive, as well as trans­ formed and tumor cell systems. The possibilities that adenoviruses afforded for the study of the molecular biology and genetics of eukaryotic cells were fully rea­ lized in the late 1960s and the 1970s.

Table of contents (9 chapters)

  • Structure and Assembly of Adenoviruses

    Philipson, Lennart

    Pages 1-52

  • The Mechanism of Adenovirus DNA Replication and the Characterization of Replication Proteins

    Sussenbach, John S. (et al.)

    Pages 53-73

  • The Origin of Adenovirus DNA Replication

    Tamanoi, Fuyuhiko (et al.)

    Pages 75-87

  • A New Mechanism for the Initiation of Replication of Φ29 and Adenovirus DNA:Priming by the Terminal Protein

    Salas, Margarita

    Pages 89-106

  • The Messenger RNAs from the Transforming Region of Human Adenoviruses

    Pettersson, Ulf (et al.)

    Pages 107-123

Buy this book

eBook $109.00
price for USA (gross)
  • ISBN 978-3-642-69460-8
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $149.00
price for USA
  • ISBN 978-3-642-69462-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
The Molecular Biology of Adenoviruses I
Book Subtitle
30 Years of Adenovirus Research 1953–1983
Editors
  • W. Doerfler
Series Title
Current Topics in Microbiology and Immunology
Series Volume
109
Copyright
1983
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-69460-8
DOI
10.1007/978-3-642-69460-8
Softcover ISBN
978-3-642-69462-2
Series ISSN
0070-217X
Edition Number
1
Number of Pages
XII, 232
Topics